GPR65 抗体 (Extracellular Loop)
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Quick Overview for GPR65 抗体 (Extracellular Loop) (ABIN7884991)
抗原
See all GPR65 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 72-84, Extracellular Loop
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原理
- A Rabbit Polyclonal Antibody to GPR68 (OGR1)
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预测反应
- Rat,mouse,human - 14,15 amino acid residues identical.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)DYTWNKDNWTFSP, corresponding to amino acid residues 72 - 84 of human GPR65
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亚型
- IgG
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anti-G Protein-Coupled Receptor 65 (GPR65) (1st Extracellular Loop), (AA 72-84) antibody
GPR65 适用: 人 IHC, FACS, LCI, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 65 (GPR65) (Extracellular Domain) antibodyGPR65 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 65 (GPR65) (1st Extracellular Loop), (AA 72-84) antibody (PE)GPR65 适用: 人 FACS 宿主: 兔 Polyclonal PE
anti-G Protein-Coupled Receptor 65 (GPR65) antibodyGPR65 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 65 (GPR65) (1st Extracellular Loop), (AA 72-84) antibody (FITC)GPR65 适用: 人 FACS, LCI 宿主: 兔 Polyclonal FITC
anti-G Protein-Coupled Receptor 65 (GPR65) (C-Term) antibodyGPR65 适用: 人, 小鼠, 大鼠, 犬, 马, Pig, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 65 (GPR65) antibodyGPR65 适用: 人, 小鼠 IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 65 (GPR65) (3rd Extracellular Domain) antibodyGPR65 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 65 (GPR65) (1st Cytoplasmic Domain) antibodyGPR65 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235434)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- GPR65 (G Protein-Coupled Receptor 65 (GPR65))
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别名
- G-protein coupled receptor 65
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背景
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Synonyms: Acid-sensing G-protein coupled receptor 68, Ovarian cancer G-protein coupled receptor 1, Sphingosylphosphorylcholine receptor
Description: All GPCRs, including GPR68, are single peptides possessing seven transmembrane domains with an extracellular N-terminus and an intracellular C-terminus1. GPR68 is expressed in several tissues including the spleen, testis, small bowel, brain, heart, lung and kidneys. It shares strong homology (49-54 % ) with the human receptor GPR42.GPR68 is proton sensitive in the pH range of 6.8-7.8 and acts as a proton activated receptor. GPR68 stimulates inositol triphosphate (IP3) formation thereby releasing intracellular calcium and activating the mitogen activated protein kinase/extracellular signal-regulated (ERK) kinase cascade. In addition, GPR68 receptor regulates NHE3 and H+-ATPase, in response to extracellular pH changes in cultured HEK 293 renal cells. This activation requires a cluster of histidine residues in the extracellular domains of the receptor and protein-kinase C (PKC) activation4.
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基因ID
- 238377
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UniProt
- Q8BFQ3
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途径
- cAMP Metabolic Process
抗原
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