EPH Receptor A5 抗体 (Extracellular, N-Term)
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Quick Overview for EPH Receptor A5 抗体 (Extracellular, N-Term) (ABIN7884937)
抗原
See all EPH Receptor A5 (EPHA5) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 357-369, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to EphA5 (Extracellular)
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预测反应
- Rat,human - 12 out of 13 amino acids identical.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KSKETSITAEGLK, corresponding to amino acid residues 357 - 369 of mouse EPHA5
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亚型
- IgG
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anti-EPH Receptor A5 (EPHA5) (AA 246-514) antibody
EPHA5 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A5 (EPHA5) (AA 942-972), (C-Term) antibodyEPHA5 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB1658 unconjugated
anti-EPH Receptor A5 (EPHA5) antibodyEPHA5 适用: 人 WB, IHC (p) 宿主: 小鼠 Monoclonal 6C4 unconjugated
anti-EPH Receptor A5 (EPHA5) (AA 1-130) antibodyEPHA5 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A5 (EPHA5) (AA 620-774) antibodyEPHA5 适用: 人 ELISA 宿主: 小鼠 Monoclonal 8B10B1 unconjugated
anti-EPH Receptor A5 (EPHA5) (Internal Region) antibodyEPHA5 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A5 (EPHA5) (AA 234-333) antibodyEPHA5 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5C3 unconjugated
anti-EPH Receptor A5 (EPHA5) (AA 234-333) antibodyEPHA5 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5C8 unconjugated
anti-EPH Receptor A5 (EPHA5) (AA 792-841) antibodyEPHA5 适用: 人, 小鼠, 大鼠, 小鸡, 猴, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, Bat, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A5 (EPHA5) (AA 1001-1032), (C-Term) antibodyEPHA5 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- EPH Receptor A5 (EPHA5)
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别名
- EPHA5
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背景
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Synonyms: Ephrin type A receptor 5, Brain specific kinase, EPHA5
Description:
EphA5 (EPH Receptor A5) is a member of the Eph receptor tyrosine kinase family, which is the largest group of receptor tyrosine kinases (RTKs) in the human genome. They are divided into two classes-EphA and EphB-based on sequence similarity and ligand binding preferences. EphA receptors (EphA1-A10) typically bind to glycosylphosphatidylinositol (GPI)-anchored ephrin-A ligands, whereas EphB receptors (EphB1-B6) bind to transmembrane ephrin-B ligands.1
EphA5 is predominantly expressed in the developing central nervous system, especially in the cortex, hippocampus, olfactory bulb, and retina. It is critically involved in axon guidance, particularly in the formation of retinotectal and thalamocortical projections, contributing to the correct mapping of neural circuits. In the adult brain, EphA5 influences dendritic spine maturation and synaptic plasticity, which are fundamental for learning and memory.2,3
Eph receptors, including EphA5, are often dysregulated in cancer. EphA5 displays context-dependent roles in cancer, acting as either a tumor suppressor or, in some cases, a tumor promoter, depending on the cellular environment and tumor type. Its role is influenced by its expression pattern, epigenetic status, and interactions with other signaling pathways.4 In certain cancers such as breast and prostate, EphA5 is downregulated, suggesting a tumor-suppressive function, while in others like lung and gastric cancer, EphA5 expression is elevated and correlates with a more aggressive cancer.5,6
All these makes EphA5 a promising target for therapeutic intervention. Indeed, recently an antibody-drug conjugate (ADC) targeting EphA5, has been developed as a highly selective target for directed anticancer therapy.7
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基因ID
- 13839
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UniProt
- Q60629
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途径
- RTK signaling
抗原
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