Cortactin 抗体 (Intracellular)
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Quick Overview for Cortactin 抗体 (Intracellular) (ABIN7884899)
抗原
See all Cortactin (CTTN) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 346-359, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Cortactin
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预测反应
- Rat,human - identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KTSNIRANFENLAK, corresponding to amino acid residues 346 - 359 of mouse Cortactin
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亚型
- IgG
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anti-Cortactin (CTTN) (N-Term) antibody
KO Validated CTTN 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cortactin (CTTN) antibodyCTTN 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-Cortactin (CTTN) (AA 214-513) antibodyCTTN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cortactin (CTTN) (AA 1-105) antibodyCTTN 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Cortactin (CTTN) (pTyr466) antibodyCTTN 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cortactin (CTTN) (AA 341-450) antibodyCTTN 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 2B5 unconjugated
anti-Cortactin (CTTN) antibodyCTTN 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 4C6 unconjugated
anti-Cortactin (CTTN) antibodyKD Validated CTTN 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB2335 unconjugated Recombinant Antibody
anti-Cortactin (CTTN) (AA 1-509) antibodyCTTN 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cortactin (CTTN) (AA 1-509) antibodyCTTN 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200-1:1000
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:300
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235169)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Cortactin (CTTN)
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别名
- Src substrate cortactin
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背景
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Synonyms: Src substrate cortactin, Oncogene EMS1, EMS1, Amplaxin, CTTN
Description: Cortical acting binding protein, Cortactin, is an actin-binding protein involved in cytoskeletal regulation1. Cortactin is a 63-65 kDa protein that consists of four major domains: N-terminal acidic (NTA), 6.5 tandems repeat, proline-rich domain, and the C-terminal Src homology 3 domains (SH3 domains)2 and it is regulated by post translational modifications such as phosphorylation and acetylation1.The actin filament network provides mechanical support as well as protrusive and contractile forces essential for directed cell motility and cell and tissue morphogenesis. Cortactin activates the Arp2/3 complex, the main regulator of actin polymerization, and thereby regulates the assembly of branched actin3.Overexpression of cortactin was shown to enhance cell migration, invasion, and tumor cell metastasis. It is also overexpressed in various types of cancer such as breast cancers as well as head and neck tumors1.
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基因ID
- 13043
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UniProt
- Q60598
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途径
- MAPK Pathway
抗原
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