Adenosine A3 Receptor 抗体 (2nd Extracellular Loop)
Our Local Distributor
北京 101111
Quick Overview for Adenosine A3 Receptor 抗体 (2nd Extracellular Loop) (ABIN7884728)
抗原
See all Adenosine A3 Receptor (ADORA3) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
-
-
抗原表位
- 2nd Extracellular Loop, AA 152-166
-
原理
- A rabbit polyclonal antibody to Human Adenosine A3 Receptor (extracellular)
-
预测反应
- Human only
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
- Peptide KLTSEYHRNVTFLSC, corresponding to amino acid residues 152 - 166 of human ADORA3
-
亚型
- IgG
-
-
anti-Adenosine A3 Receptor (ADORA3) (AA 85-180) antibody
ADORA3 适用: 人, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A3 Receptor (ADORA3) antibodyADORA3 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A3 Receptor (ADORA3) (AA 121-225) antibodyADORA3 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1A3 unconjugated
anti-Adenosine A3 Receptor (ADORA3) (C-Term) antibodyADORA3 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A3 Receptor (ADORA3) (C-Term) antibodyADORA3 适用: 人, Pig, Cow, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A3 Receptor (ADORA3) (AA 149-161), (Extracellular), (Loop 2) antibodyADORA3 适用: 小鼠 WB, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A3 Receptor (ADORA3) (3rd Intracellular Loop), (AA 216-230) antibodyADORA3 适用: 人 WB, IF, IHC, IC 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A3 Receptor (ADORA3) (AA 202-232) antibodyADORA3 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB53326 unconjugated
anti-Adenosine A3 Receptor (ADORA3) (C-Term) antibodyADORA3 适用: 人, 小鼠 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A3 Receptor (ADORA3) (Cytoplasmic Domain) antibodyADORA3 适用: 人, Pig, 犬, 马, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- The optimal concentration should be determined by the user
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 0.2 mL double distilled water (DDW).
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4
-
储存液
- Without preservative
-
储存条件
- -20 °C
-
储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
-
-
- Adenosine A3 Receptor (ADORA3)
-
别名
- ADORA3
-
背景
-
Synonyms: Adenosine receptor A3, A3AR, AA3R, ADORA3
Description:
Adenosine A3 receptor (also known as ADORA3), is a member of the G protein-coupled receptor (GPCR) family that plays a crucial role in regulating a wide range of physiological processes, especially those related to inflammation, immunity, and cell survival. It is one of four receptors activated by adenosine, a purine nucleoside that functions as a local modulator of cellular activity in response to stress, hypoxia, or tissue damage.1
Encoded by the ADORA3 gene, this receptor is primarily coupled to Gi/o proteins, resulting in the inhibition of adenylate cyclase and a subsequent decrease in cyclic AMP (cAMP) levels. Beyond this classical signaling pathway, ADORA3 activation triggers multiple intracellular cascades, such as MAPK/ERK, PI3K/Akt, and PLCβ/DAG/IP3, which together regulate critical cellular functions including apoptosis, proliferation, cytokine production, and oxidative stress responses.1,2
The ADORA3 receptor is broadly expressed across various tissues, including immune cells, the central nervous system, cardiac tissue, lungs, and liver. In immune cells such as neutrophils, mast cells, and lymphocytes, ADORA3 plays a key anti-inflammatory role by modulating cytokine secretion and reducing the activation of pro-inflammatory pathways. This has made it a target of interest in the treatment of autoimmune and inflammatory diseases like rheumatoid arthritis, inflammatory bowel disease, and psoriasis.2,3,4
In oncology, ADORA3 is often overexpressed in various tumors, including breast, colon, and melanoma cancers. Its activation in cancer cells can lead to apoptosis and inhibition of angiogenesis, positioning it as a potential target for anticancer therapies. Interestingly, it may exert opposite effects in different cellular environments, reflecting its complex and context-dependent nature.4,5
In summary, the ADORA3 receptor is a multifaceted regulatory molecule at the crossroads of inflammation, immunity, cardiovascular protection, and cancer biology. Its unique signaling capabilities and tissue-specific roles make it a compelling target for drug development, particularly in diseases characterized by chronic inflammation or uncontrolled cell growth.
-
基因ID
- 140
-
UniProt
- P0DMS8
-
途径
- Hormone Transport, cAMP Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
抗原
-
