Recombinant ZYX 抗体
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Quick Overview for Recombinant ZYX 抗体 (ABIN7882735)
抗原
See all ZYX 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- ZYX Antibody / Zyxin
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human Zyxin was used as the immunogen for the Zyxin antibody.
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亚型
- IgG
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anti-Zyxin (ZYX) (AA 1-572) antibody
ZYX 适用: 人 WB, ELISA, IP, IF, RNAi 宿主: 小鼠 Monoclonal 2C10-4A7 unconjugated
anti-Zyxin (ZYX) (AA 1-572) antibodyZYX 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2D1 unconjugated
anti-Zyxin (ZYX) (Internal Region) antibodyZYX 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Zyxin (ZYX) antibodyZYX 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Zyxin (ZYX) (AA 1-300) antibodyZYX 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Zyxin (ZYX) (Middle Region) antibodyZYX 适用: 人, 大鼠, Cow, 犬, 豚鼠, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Zyxin (ZYX) (AA 1-572) antibodyZYX 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Zyxin (ZYX) (AA 1-573) antibodyZYX 适用: 人, 小鼠 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2D1 unconjugated
anti-Zyxin (ZYX) antibodyKD Validated ZYX 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB3585 unconjugated Recombinant Antibody
anti-Zyxin (ZYX) (Middle Region) antibodyZYX 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Zyxin antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the Zyxin antibody at -20oC.
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- ZYX (Zyxin (ZYX))
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别名
- ZYX
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背景
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The Zyxin antibody targets Zyxin, a LIM domain-containing cytoskeletal protein encoded by the ZYX gene. Zyxin functions as a scaffold that connects the actin cytoskeleton to signaling pathways controlling cell adhesion, migration, and mechanical stress responses. It localizes to focal adhesions and stress fibers, where it interacts with actin-binding and signaling proteins to regulate cytoskeletal dynamics. The Zyxin antibody enables specific detection of this mechanosensitive protein in studies of cell motility, tissue architecture, and mechanotransduction.
Zyxin is characterized by three LIM domains at its C-terminus, which mediate protein-protein interactions, and a proline-rich N-terminal region that binds to VASP and alpha-actinin. Through these domains, Zyxin coordinates actin filament assembly and cell-matrix adhesion. The Zyxin antibody supports visualization of these interactions, allowing researchers to examine how this structural adaptor transduces mechanical cues into gene expression changes. Zyxin relocates to the nucleus in response to stress, suggesting a dual cytoplasmic and nuclear role in mechanosignaling.
As a component of focal adhesions, Zyxin participates in processes such as wound healing, embryonic development, and tissue remodeling. It interacts with proteins including LPP, LIMD1, and Ena/VASP to modulate cell shape and movement. The Zyxin antibody supports functional studies of these interactions, revealing how Zyxin integrates extracellular matrix forces with actin cytoskeletal organization. Its recruitment to sites of mechanical strain makes it a critical sensor for cellular adaptation to physical stress.
Altered Zyxin expression has been associated with several diseases, including cancer, cardiovascular dysfunction, and fibrotic disorders. Overexpression can enhance migration and invasion in certain tumors, while loss impairs cytoskeletal resilience. The Zyxin antibody is widely used to investigate its role in metastasis, cell adhesion signaling, and smooth muscle plasticity. Studies have also linked Zyxin to stretch-activated signaling in cardiac and vascular cells, highlighting its contribution to mechanobiology.
The Zyxin antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, producing distinct cytoplasmic and focal adhesion staining. NSJ Bioreagents provides this antibody as a validated reagent with strong specificity and reproducibility for use in cell biology, developmental, and oncology research. By enabling detailed analysis of Zyxin localization and expression, the Zyxin antibody supports discovery into the molecular coordination of cytoskeletal dynamics, adhesion signaling, and mechanical stress response. -
UniProt
- Q15942
抗原
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