Recombinant UFD1L 抗体
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北京 101111
Quick Overview for Recombinant UFD1L 抗体 (ABIN7882625)
抗原
See all UFD1L 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- UFD1L Antibody / Ubiquitin Fusion Degradation 1 Like
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human UFD1L was used as the immunogen for the UFD1L antibody.
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亚型
- IgG
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anti-Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L) (AA 208-307) antibody
UFD1L 适用: 人 IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 4F11A4 unconjugated
anti-Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L) (AA 208-307) antibodyUFD1L 适用: 人 WB, IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 2A6F3 unconjugated
anti-Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L) (full length) antibodyUFD1L 适用: 人, 小鼠 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L) (Internal Region) antibodyUFD1L 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L) (AA 1-307) antibodyUFD1L 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L) (AA 1-307) antibodyUFD1L 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L) antibodyKD Validated UFD1L 适用: 人 WB 宿主: 兔 Monoclonal 25GB7980 unconjugated Recombinant Antibody
anti-Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L) (AA 161-210) antibodyUFD1L 适用: 人, 大鼠, 犬, 豚鼠, 马, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L) antibodyUFD1L 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L) (AA 175-225) antibodyUFD1L 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the UFD1L antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the UFD1L antibody at -20oC.
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- UFD1L (Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L))
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别名
- UFD1L
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背景
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UFD1L antibody detects Ubiquitin fusion degradation protein 1 like, encoded by the UFD1L gene. Ubiquitin fusion degradation protein 1 like forms a complex with NPL4 and the ATPase p97/VCP to regulate extraction of ubiquitinated substrates from membranes and protein complexes. This activity is essential for protein quality control, endoplasmic reticulum associated degradation, and mitotic progression. UFD1L antibody provides researchers with an important tool for studying ubiquitin signaling, proteostasis, and cell cycle regulation.
The UFD1L-NPL4-p97 complex functions as a segregase, using ATP hydrolysis to unfold and extract ubiquitinated proteins for degradation by the proteasome. Research using UFD1L antibody has demonstrated that this complex acts in multiple pathways, including clearance of misfolded proteins from the endoplasmic reticulum, disassembly of protein aggregates, and regulation of spindle assembly during mitosis. Its versatile roles make UFD1L a central hub in protein quality control networks.
Mutations and deletions involving UFD1L are associated with genetic disorders. Studies with UFD1L antibody have shown that haploinsufficiency contributes to DiGeorge syndrome, a developmental disorder characterized by congenital heart defects, immune dysfunction, and craniofacial anomalies. Because UFD1L is located in the 22q11 region, deletions that remove this gene disrupt proteostasis during development, contributing to disease phenotypes.
In cancer biology, UFD1L has been implicated in regulating cell proliferation and survival. Research using UFD1L antibody has revealed that overexpression enhances proteasomal degradation of regulatory proteins, supporting uncontrolled growth. Conversely, loss of function can cause accumulation of toxic aggregates, impairing viability. These dual roles highlight its importance in maintaining balanced proteostasis across different contexts.
UFD1L antibody is widely used in western blotting, immunohistochemistry, and immunoprecipitation. Western blotting identifies endogenous levels, immunohistochemistry localizes expression in developmental tissues, and immunoprecipitation demonstrates interactions with p97/VCP and NPL4. These applications make UFD1L antibody essential in both developmental and disease research.
By supplying validated UFD1L antibody reagents, NSJ Bioreagents supports studies into proteostasis, ER associated degradation, and developmental biology. Detection of Ubiquitin fusion degradation protein 1 like provides insight into how protein quality control influences health and disease. -
UniProt
- Q92890
抗原
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