TFAM 抗体
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北京 101111
Quick Overview for TFAM 抗体 (ABIN7882519)
抗原
See all TFAM 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- mtTFA Antibody
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序列
- EMKSWEEQMI EVGRKDLLRR TIKKQRKY
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纯化方法
- Affinity purified
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免疫原
- Amino acids EMKSWEEQMIEVGRKDLLRRTIKKQRKY were used as the immunogen for the mtTFA antibody.
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亚型
- IgG2b
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anti-Transcription Factor A, Mitochondrial (TFAM) (N-Term) antibody
TFAM 适用: 人, 小鼠, 兔, Cow, 犬, 豚鼠, 马, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor A, Mitochondrial (TFAM) (AA 43-243) antibodyTFAM 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor A, Mitochondrial (TFAM) (AA 1-220) antibodyTFAM 适用: 人 WB, IHC, IF, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor A, Mitochondrial (TFAM) (AA 216-246), (C-Term) antibodyTFAM 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB27631 unconjugated
anti-Transcription Factor A, Mitochondrial (TFAM) (AA 1-246) antibodyTFAM 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Transcription Factor A, Mitochondrial (TFAM) antibodyKO Validated TFAM 适用: 人 WB, IF, IP, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor A, Mitochondrial (TFAM) (AA 227-246), (C-Term) antibodyTFAM 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor A, Mitochondrial (TFAM) (AA 1-246) antibodyTFAM 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor A, Mitochondrial (TFAM) (AA 216-246) antibodyTFAM 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Transcription Factor A, Mitochondrial (TFAM) (AA 214-241), (N-Term) antibodyTFAM 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the mtTFA antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the mtTFA antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TFAM (Transcription Factor A, Mitochondrial (TFAM))
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别名
- mtTFA
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背景
- TFAM (Transcription factor A, mitochondrial), also known as TCF6 or TCF6L2, is a 162-amino acid protein that activates transcription of each mitochondrial DNA (mtDNA) strand by binding to an element of approximately 30 nucleotides present in both the light-strand and the heavy-strand promoters. By Southern blot analysis of restriction enzyme digests of human/Chinese hamster somatic cell hybrid lines, Milatovich et al. (1992) mapped TFAM sequences, which they called MTTF1, to 3 different chromosomes: chromosomes 10, 7p, and 11q. By PCR-based screening of a somatic cell hybrid panel and by fluorescence in situ hybridization, Scott (2007) stated that the sequences mapped to chromosomes 7p (TCF6L1) and 11q (MTTF1, or TCF6L3) are pseudogenes. Larsson et al. (1997) mapped the mouse mitochondrial transcription factor A gene (Tfam) to the central part of mouse chromosome 10. This region exhibits syntenic homology with human 10q21. Mitochondrial transcription factor A is a key activator of mitochondrial transcription in mammals. It also has a role in mitochondrial DNA replication, since transcription generates an RNA primer necessary for initiation of mtDNA replication.
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UniProt
- Q00059
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途径
- Chromatin Binding
抗原
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