Recombinant TARDBP 抗体
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Quick Overview for Recombinant TARDBP 抗体 (ABIN7882427)
抗原
See all TARDBP 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- TAR DNA binding protein 43 Antibody / TDP43 / TARDBP
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纯化方法
- Affinity chromatography
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免疫原
- A peptide sequence specific to TAR DNA binding protein 43 was used as the immunogen for the TAR DNA binding protein 43 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the TAR DNA binding protein 43 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TAR DNA binding protein 43 Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TARDBP (TAR DNA Binding Protein (TARDBP))
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别名
- TAR DNA binding protein 43
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背景
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TAR DNA binding protein 43 is a DNA/RNA-binding protein that shuttles between nucleus and cytoplasm to coordinate RNA metabolism. It recognizes UG-rich sequences via 2 RNA recognition motifs and uses a glycine-rich C-terminus to assemble ribonucleoprotein complexes. TAR DNA binding protein 43 regulates alternative splicing, transcript stability, 3' end processing, and mRNA transport, integrating these steps with transcription-coupled RNA handling across diverse cell types.
It participates in stress-responsive RNA granule dynamics and controlled phase behavior, linking RNA sorting to protein quality control pathways. Its nuclear enrichment, regulated export, and post-translational modification states offer quantitative readouts for studies of RNA processing, trafficking, and cellular adaptation in defined model systems.
The TAR DNA binding protein 43 antibody from NSJ Bioreagents enables specific detection of endogenous TDP-43 in applications such as western blot, immunofluorescence, immunohistochemistry, immunoprecipitation, and RNA-protein pulldown workflows. Researchers use the TAR DNA binding protein 43 antibody to measure total protein levels, assess nuclear-cytoplasmic distribution, and evaluate biochemical fractionation or stress-induced relocalization when paired with appropriate complementary reagents. With high specificity and reproducible performance, the TAR DNA binding protein 43 antibody supports rigorous analysis of RNA-binding protein networks and post-transcriptional regulation.
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UniProt
- Q13148
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途径
- Positive Regulation of Peptide Hormone Secretion
抗原
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