Recombinant SOCS7 抗体
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Quick Overview for Recombinant SOCS7 抗体 (ABIN7882392)
抗原
See all SOCS7 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- SOCS7 Antibody / Suppressor of cytokine signaling 7
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human SOCS7 was used as the immunogen for the SOCS7 antibody.
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亚型
- IgG
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anti-Suppressor of Cytokine Signaling 7 (SOCS7) (AA 6-165) antibody
SOCS7 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Cytokine Signaling 7 (SOCS7) antibodySOCS7 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB1820 unconjugated Recombinant Antibody
anti-Suppressor of Cytokine Signaling 7 (SOCS7) (N-Term) antibodySOCS7 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Cytokine Signaling 7 (SOCS7) (Internal Region) antibodyVerified SOCS7 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Suppressor of Cytokine Signaling 7 (SOCS7) (AA 35-84) antibodySOCS7 适用: 人, 小鼠, 大鼠, Cow, 兔, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Cytokine Signaling 7 (SOCS7) (AA 458-486), (C-Term) antibodySOCS7 适用: 人 WB 宿主: 兔 Polyclonal RB37084 unconjugated
anti-Suppressor of Cytokine Signaling 7 (SOCS7) (AA 458-486) antibodySOCS7 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SOCS7 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the SOCS7 antibody at -20oC.
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- SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))
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别名
- SOCS7
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背景
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SOCS7 antibody detects Suppressor of cytokine signaling 7, encoded by the SOCS7 gene. Suppressor of cytokine signaling 7 belongs to the SOCS family of proteins that negatively regulate cytokine and growth factor signaling through the JAK-STAT pathway. By acting as feedback inhibitors, SOCS proteins help maintain immune balance and prevent excessive signaling. SOCS7 antibody provides researchers with a key reagent to study signal regulation, immune homeostasis, and disease.
Suppressor of cytokine signaling 7 contains a central SH2 domain and a C terminal SOCS box, which targets signaling complexes for ubiquitination and proteasomal degradation. Research using SOCS7 antibody has shown that it regulates not only STAT pathways but also insulin receptor and growth factor receptor signaling. This broadens its role beyond immune regulation into metabolism and growth control. Because it functions as a scaffold that recruits ubiquitin ligases, SOCS7 coordinates protein turnover of key signaling mediators.
In addition to its signaling roles, SOCS7 has nuclear functions. Studies with SOCS7 antibody have demonstrated that the protein translocates to the nucleus in response to DNA damage and stress, where it interacts with signaling and structural proteins to regulate cell cycle checkpoints. This nuclear activity links SOCS7 to genome stability and cellular stress responses, making it more than a classic negative regulator of cytokines.
Dysregulation of SOCS7 contributes to disease. Reduced expression can lead to prolonged signaling through pathways such as STAT3, promoting inflammation and tumorigenesis. Elevated expression may impair insulin signaling and contribute to metabolic imbalance. Research using SOCS7 antibody has explored its roles in autoimmune disease, cancer, and diabetes. By influencing multiple pathways, SOCS7 serves as a critical checkpoint in cellular signaling.
SOCS7 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting demonstrates protein abundance and post-translational modifications, immunohistochemistry highlights expression patterns in tissues such as spleen and pancreas, and immunofluorescence reveals subcellular distribution, including nuclear translocation. These applications make SOCS7 antibody an indispensable tool in signaling research.
By providing validated SOCS7 antibody reagents, NSJ Bioreagents supports studies into cytokine signaling, metabolism, and cancer biology. Detection of Suppressor of cytokine signaling 7 enables researchers to better understand how signaling feedback loops are maintained and disrupted in disease. -
UniProt
- O14512
抗原
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