Recombinant SDHB 抗体
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北京 101111
Quick Overview for Recombinant SDHB 抗体 (ABIN7882383)
抗原
See all SDHB 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- SDHB Antibody / Succinate dehydrogenase subunit B
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human SDHB was used as the immunogen for the SDHB antibody.
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亚型
- IgG
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anti-Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) (AA 97-282) antibody
SDHB 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) (AA 29-280) antibodySDHB 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) (AA 29-280) antibodySDHB 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 2B2B1 unconjugated
anti-Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) (C-Term) antibodySDHB 适用: 人, 小鼠 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) (Middle Region) antibodySDHB 适用: 人, 小鼠, 大鼠, 斑马鱼, 豚鼠, 兔, Cow, 犬, 马, 山羊, Saccharomyces cerevisiae WB 宿主: 兔 Polyclonal unconjugated
anti-Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) antibodySDHB 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Monoclonal 7D12 unconjugated Recombinant Antibody
anti-Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) (AA 1-280) antibodySDHB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) antibodySDHB 适用: 人 IHC 宿主: 兔 Monoclonal HMV320 unconjugated Recombinant Antibody
anti-Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) antibodySDHB 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) (AA 29-280) antibodySDHB 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SDHB antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the SDHB antibody at -20oC.
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- SDHB (Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB))
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别名
- SDHB
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背景
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SDHB antibody detects succinate dehydrogenase complex iron sulfur subunit B, encoded by the SDHB gene. SDHB is a core component of mitochondrial complex II, which functions in both the tricarboxylic acid cycle and the electron transport chain. It binds iron sulfur clusters that mediate electron transfer from succinate to ubiquinone. Through this activity, SDHB is essential for mitochondrial energy metabolism and cellular respiration.
SDHB antibody is widely used in studies of mitochondrial biology, metabolism, and cancer. Loss of SDHB expression is associated with hereditary paraganglioma pheochromocytoma syndromes and other mitochondrial disorders. Tumors with SDHB mutations display altered metabolic profiles characterized by accumulation of succinate and stabilization of hypoxia inducible factors. By detecting SDHB, researchers can investigate the links between mitochondrial dysfunction and tumorigenesis.
In western blot assays, SDHB antibody identifies protein bands of the expected molecular weight in mitochondrial fractions. Immunohistochemistry highlights mitochondrial distribution in tissues, while immunofluorescence reveals punctate staining consistent with mitochondrial localization. These applications enable precise analysis of SDHB expression.
SDHB deficiency contributes to cancer development by altering redox balance, epigenetic regulation, and signaling pathways. By applying SDHB antibody, scientists can study how mitochondrial complex II dysfunction promotes tumorigenesis and impacts cellular metabolism. It is also valuable for identifying SDHB deficient tumors in diagnostic pathology.
Beyond oncology, SDHB plays roles in neurology and cardiology, where mitochondrial function is critical for tissue survival. Mutations in SDHB contribute to metabolic and degenerative diseases affecting high energy demanding tissues. SDHB antibody therefore provides a versatile tool for investigating mitochondrial biology in health and disease.
SDHB antibody from NSJ Bioreagents provides reliable specificity for studying mitochondrial metabolism, tumorigenesis, and energy homeostasis. Its strong performance across applications ensures accurate detection of SDHB in diverse research contexts. -
UniProt
- P21912
抗原
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