SKIP 抗体
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北京 101111
Quick Overview for SKIP 抗体 (ABIN7882277)
抗原
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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原理
- SKIP Antibody / SNW1 / NCoA-62 (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant fragment of human protein was used as the immunogen for the SKIP antibody.
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亚型
- IgG2a
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应用备注
- Optimal dilution of the SKIP antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the SKIP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- SKIP
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背景
- Nuclear receptor coactivator NCOA62/SNW1 (also called Nuclear Protein SkiP, SKIIP, Ski-interacting protein) is a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also interact with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.
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UniProt
- Q13573
抗原
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