Recombinant PSMC5 抗体
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Quick Overview for Recombinant PSMC5 抗体 (ABIN7882067)
抗原
See all PSMC5 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PSMC5 Antibody / 26S proteasome regulatory subunit 8
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human PSMC5 was used as the immunogen for the PSMC5 antibody.
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亚型
- IgG
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anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 (PSMC5) antibody
PSMC5 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 (PSMC5) (Center) antibodyPSMC5 适用: 人, 小鼠, 大鼠 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 (PSMC5) (AA 127-406) antibodyPSMC5 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 (PSMC5) antibodyPSMC5 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 24GB1500 unconjugated Recombinant Antibody
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 (PSMC5) (C-Term) antibodyPSMC5 适用: 人, 小鼠, 大鼠, 斑马鱼, Cow, 豚鼠, 马, 兔 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 (PSMC5) antibodyPSMC5 适用: 人 WB, ICC, DB 宿主: 小鼠 Monoclonal 2837C4a unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 (PSMC5) (Internal Region) antibodyPSMC5 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 (PSMC5) (AA 253-324), (Regulatory Subunit) antibodyPSMC5 适用: 人 WB, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 (PSMC5) antibodyPSMC5 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 (PSMC5) (C-Term) antibodyPSMC5 适用: 人, 小鼠, 大鼠, 斑马鱼, Cow, 犬, Pig, 非洲爪蟾, Drosophila melanogaster, C. elegans WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PSMC5 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the PSMC5 antibody at -20oC.
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- PSMC5 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 (PSMC5))
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别名
- PSMC5
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背景
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PSMC5 antibody detects 26S proteasome regulatory subunit 8, encoded by the PSMC5 gene. This protein is one of the six ATPases of the AAA family that form the base of the 19S regulatory particle of the proteasome. PSMC5, also known as TBP1, provides ATP hydrolysis required for unfolding and translocating ubiquitinated substrates into the 20S core particle for degradation. PSMC5 antibody provides researchers with a reliable tool to study protein homeostasis, cell cycle regulation, and signaling pathways dependent on proteasomal degradation.
The 26S proteasome is responsible for the majority of regulated intracellular protein degradation in eukaryotic cells. By removing misfolded proteins, damaged proteins, and short lived regulatory proteins, the proteasome maintains proteostasis and controls key signaling events. Research using PSMC5 antibody has shown that 26S proteasome regulatory subunit 8 contributes to ATP driven unfolding, ensuring substrate entry into the proteolytic chamber. This function is essential for turnover of cell cycle regulators, transcription factors, and signal transduction intermediates.
Dysfunction of the proteasome contributes to numerous diseases, including neurodegenerative disorders such as Parkinson and Alzheimer disease, where accumulation of protein aggregates is a hallmark. Research with PSMC5 antibody has demonstrated that altered proteasome activity leads to impaired clearance of aggregation prone proteins. In cancer, hyperactivation of the proteasome allows degradation of tumor suppressors and cell cycle inhibitors, promoting unchecked proliferation. PSMC5 has also been implicated in immune regulation, where proteasomal processing generates antigenic peptides presented on MHC class I molecules.
PSMC5 antibody is widely used in western blotting, immunoprecipitation, and immunohistochemistry. Western blotting demonstrates abundance in metabolically active tissues, while immunoprecipitation allows isolation of 19S regulatory complexes containing PSMC5. Immunohistochemistry highlights proteasome distribution in brain, muscle, and immune organs. These applications make PSMC5 antibody versatile in both fundamental and translational research.
By supplying validated PSMC5 antibody reagents, NSJ Bioreagents supports research into proteasome biology, neurodegeneration, and oncology. Detection of 26S proteasome regulatory subunit 8 ensures that researchers can examine how protein degradation maintains cellular health and contributes to disease when dysregulated. -
UniProt
- P62195
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途径
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway
抗原
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