PKD1 抗体
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北京 101111
Quick Overview for PKD1 抗体 (ABIN7881995)
抗原
See all PKD1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Polycystin 1 Antibody / PKD1
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序列
- RTPLRAKNKV HP
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纯化方法
- Antigen affinity
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免疫原
- Amino acids RTPLRAKNKVHP were used as the immunogen for this Polycystin 1 antibody.
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亚型
- Ig Fraction
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anti-Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) (AA 651-876) antibody
PKD1 适用: 人 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) (AA 131-230) antibodyPKD1 适用: 人, 小鼠 ELISA, WB, FACS, IF (cc), IF (p), ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) (AA 615-753) antibodyPKD1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) (AA 349-612) antibodyPKD1 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) (Thr266), (Thr312) antibodyPKD1 适用: 人, 小鼠, 大鼠 IHC, ELISA, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) (AA 3682-3873) antibodyPKD1 适用: 人 ELISA, FACS 宿主: 大鼠 Monoclonal 8C3D11 unconjugated
anti-Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) (pSer205) antibodyPKD1 适用: 人, 小鼠, 大鼠 IHC, ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) (pSer910) antibodyPKD1 适用: 人, 小鼠, 大鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Polycystin 1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- 0.5 mg/mL in 1X TBS, pH 7.3, with 0.5 % BSA (US sourced) and 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot and store the Polycystin 1 antibody at -20oC.
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- PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))
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别名
- Polycystin 1
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背景
- Polycystin 1, also known as PKD1, is a protein encoded by the PKD1 gene and is crucial in the development of Polycystic Kidney Disease (PKD). PKD1 mutations are responsible for the majority of cases of autosomal dominant PKD, a genetic disorder that causes the formation of fluid-filled cysts in the kidneys. Polycystin 1 is a transmembrane protein that plays a vital role in cell-cell and cell-matrix interactions. It is primarily expressed in the kidneys, liver, pancreas, and other tissues, where it helps regulate cell proliferation, differentiation, and apoptosis. Dysfunction of Polycystin 1 disrupts these essential cellular processes, leading to the formation of cysts in the kidneys. Research has shown that Polycystin 1 interacts with other proteins, such as Polycystin 2, to form a protein complex that regulates calcium signaling and cell growth. Mutations in PKD1 disrupt this complex, causing aberrant calcium signaling and uncontrolled cell proliferation, which ultimately results in cyst formation and kidney damage. Studies have also suggested that Polycystin 1 may play a role in the mechanosensory function of kidney epithelial cells, allowing them to respond to changes in fluid flow and pressure within the nephron. Dysregulation of this mechanosensory function due to PKD1 mutations may contribute to the development and progression of PKD.
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途径
- Myometrial Relaxation and Contraction, Maintenance of Protein Location
抗原
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