Recombinant Pleiotrophin 抗体
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北京 101111
Quick Overview for Recombinant Pleiotrophin 抗体 (ABIN7881982)
抗原
See all Pleiotrophin (PTN) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Pleiotrophin Antibody / PTN
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human Pleiotrophin was used as the immunogen for the Pleiotrophin antibody.
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亚型
- IgG
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anti-Pleiotrophin (PTN) (AA 45-154) antibody
PTN 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 5C3 unconjugated
anti-Pleiotrophin (PTN) (Internal Region) antibodyPTN 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Pleiotrophin (PTN) (AA 33-168) antibodyPTN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Pleiotrophin (PTN) (AA 127-154), (C-Term) antibodyPTN 适用: 人, 小鼠, 大鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB14477 unconjugated
anti-Pleiotrophin (PTN) (AA 101-168) antibodyPTN 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Pleiotrophin (PTN) (AA 33-168) antibodyPTN 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pleiotrophin (PTN) (AA 33-168) antibodyPTN 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Pleiotrophin (PTN) (AA 33-168) antibodyPTN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pleiotrophin (PTN) (AA 150-168), (C-Term) antibodyPTN 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Pleiotrophin (PTN) (Internal Region) antibodyVerified PTN 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Pleiotrophin antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the Pleiotrophin antibody at -20oC.
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- Pleiotrophin (PTN)
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别名
- Pleiotrophin
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背景
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Pleiotrophin antibody detects pleiotrophin, a secreted heparin binding growth factor encoded by the PTN gene. Pleiotrophin is a cytokine involved in the regulation of cell growth, survival, differentiation, and migration. It is highly expressed during embryonic development, where it contributes to neurogenesis, angiogenesis, and skeletal formation. In adult tissues, pleiotrophin expression is limited but becomes re induced during tissue repair and tumorigenesis.
Pleiotrophin antibody is applied in developmental biology, oncology, and regenerative medicine research. The protein interacts with receptors such as receptor protein tyrosine phosphatase beta zeta, syndecans, and anaplastic lymphoma kinase, activating signaling cascades including PI3K AKT and MAPK. These pathways promote proliferation and survival, making pleiotrophin an important regulator of both physiological and pathological growth. Detecting pleiotrophin provides insight into how extracellular cues influence signaling and cell fate decisions.
The antibody is validated for western blotting, immunohistochemistry, immunofluorescence, and ELISA. In western blot assays, pleiotrophin antibody identifies bands corresponding to the growth factor across tissue extracts. Immunohistochemistry reveals expression in vasculature and developing tissues, while immunofluorescence highlights extracellular distribution and receptor colocalization. ELISA applications allow quantification of secreted pleiotrophin in culture media or patient samples.
Overexpression of pleiotrophin has been reported in cancers including glioblastoma, breast carcinoma, and prostate cancer. In these contexts, pleiotrophin enhances angiogenesis, invasion, and tumor progression. By applying pleiotrophin antibody, scientists can evaluate pleiotrophin levels as a biomarker and investigate its potential as a therapeutic target.
In neuroscience, pleiotrophin plays roles in neuronal survival, synaptic plasticity, and axonal regeneration after injury. It promotes neurite outgrowth and supports recovery in models of neural damage. In skeletal biology, pleiotrophin regulates osteoblast differentiation and bone growth, linking it to both normal development and fracture healing. These diverse functions demonstrate the broad research value of pleiotrophin antibody.
Pleiotrophin antibody provided by NSJ Bioreagents offers reliable specificity for detecting this multifunctional growth factor. Its strong performance across multiple applications makes it an important tool for investigating pleiotrophin in development, disease, and regeneration. -
UniProt
- P21246
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途径
- RTK signaling
抗原
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