PLAT 抗体
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北京 101111
Quick Overview for PLAT 抗体 (ABIN7881957)
抗原
See all PLAT 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- tPA Antibody / Tissue Plasminogen Activator
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序列
- QKDVPGVYTK VTNYLDWIRD NMRP
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纯化方法
- Antigen affinity purified
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免疫原
- Amino acids QKDVPGVYTKVTNYLDWIRDNMRP from the human protein were used as the immunogen for the tPA antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the tPA antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the tPA antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PLAT (Plasminogen Activator, Tissue (PLAT))
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别名
- tPA
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背景
- PLAT is also known as tPA. This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
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UniProt
- P00750
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途径
- Autophagy, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, SARS-CoV-2 Protein Interactome
抗原
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