Recombinant HRPT2 抗体
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北京 101111
Quick Overview for Recombinant HRPT2 抗体 (ABIN7881901)
抗原
See all HRPT2 (CDC73) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- CDC73 Antibody / Cell division cycle protein 73
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human HRPT2 / CDC73 was used as the immunogen for the CDC73 antibody.
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亚型
- IgG
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anti-Parafibromin (CDC73) (AA 132-161) antibody
CDC73 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB23239 unconjugated
anti-Parafibromin (CDC73) antibodyKD Validated CDC73 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB3450 unconjugated Recombinant Antibody
anti-Parafibromin (CDC73) (AA 127-161) antibodyCDC73 适用: 人 WB 宿主: 兔 Polyclonal RB30818 unconjugated
anti-Parafibromin (CDC73) (AA 74-346) antibodyCDC73 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Parafibromin (CDC73) (AA 250-300) antibodyCDC73 适用: 人, 小鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Parafibromin (CDC73) (AA 119-520) antibodyCDC73 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Parafibromin (CDC73) antibodyKD Validated CDC73 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Monoclonal unconjugated Recombinant Antibody
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应用备注
- Optimal dilution of the CDC73 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the CDC73 antibody at -20oC.
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- HRPT2 (CDC73) (Parafibromin (CDC73))
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别名
- CDC73
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背景
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CDC73 antibody detects cell division cycle protein 73, a tumor suppressor encoded by the CDC73 gene. CDC73 is also known as parafibromin and functions as a subunit of the PAF1 transcriptional regulatory complex. Through its association with RNA polymerase II, CDC73 regulates transcription elongation, histone modification, and RNA processing. Its tumor suppressor activity is critical for preventing uncontrolled cell growth and maintaining genomic integrity.
CDC73 antibody is widely applied in cancer research, molecular biology, and genetic studies. Mutations in CDC73 are associated with hyperparathyroidism-jaw tumor syndrome and parathyroid carcinoma. By detecting CDC73 expression, researchers can investigate its role in tumor suppression and transcriptional control. Loss of CDC73 expression serves as a diagnostic marker for parathyroid malignancy and supports studies of endocrine tumors.
Western blot assays reveal CDC73 protein in nuclear extracts, while immunohistochemistry highlights nuclear localization in normal tissues and its loss in tumor samples. Immunofluorescence provides high-resolution visualization of parafibromin within nuclear transcriptional complexes. These applications make CDC73 antibody valuable for both research and diagnostic contexts.
CDC73 also regulates histone methylation and chromatin remodeling through its interaction with the PAF1 complex. This regulation influences expression of genes involved in cell cycle, apoptosis, and development. By applying CDC73 antibody, scientists can study how transcriptional regulation by parafibromin contributes to normal growth and cancer prevention.
CDC73 antibody from NSJ Bioreagents provides strong specificity for analyzing tumor suppressor function and transcriptional regulation. Its performance across applications ensures accurate results for basic research, oncology, and clinical pathology. -
UniProt
- Q6P1J9
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途径
- Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance
抗原
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