Recombinant Nucleolin 抗体
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北京 101111
Quick Overview for Recombinant Nucleolin 抗体 (ABIN7881852)
抗原
See all Nucleolin (NCL) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- NCL Antibody / Nucleolin
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human Nucleolin was used as the immunogen for the NCL antibody.
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亚型
- IgG
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anti-Nucleolin (NCL) (AA 353-568) antibody
NCL 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nucleolin (NCL) antibodyNCL 适用: 人 WB, IHC, IF, FACS 宿主: 小鼠 Monoclonal NCL-902 unconjugated
anti-Nucleolin (NCL) antibodyNCL 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Nucleolin (NCL) (AA 388-569) antibodyNCL 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nucleolin (NCL) antibodyNCL 适用: 人 WB, IHC, IF, FACS, ISt 宿主: 小鼠 Monoclonal NCL-902 unconjugated
anti-Nucleolin (NCL) antibodyNCL 适用: 人 WB, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 364-5-NCL-902 unconjugated
anti-Nucleolin (NCL) antibodyCarrier-free NCL 适用: 人, 小鼠, 大鼠 WB, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal NCL-902 unconjugated
anti-Nucleolin (NCL) antibodyNCL 适用: 人, 小鼠, 大鼠 WB, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal NCL-902 unconjugated
anti-Nucleolin (NCL) (AA 425-455) antibodyNCL 适用: 人 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Nucleolin (NCL) (AA 428-455) antibodyNCL 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB17464 unconjugated
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应用备注
- Optimal dilution of the NCL antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the NCL antibody at -20oC.
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- Nucleolin (NCL)
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别名
- NCL
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背景
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NCL antibody detects nucleolin, a multifunctional nucleolar protein involved in ribosome biogenesis, RNA metabolism, and chromatin organization. Nucleolin is one of the most abundant nucleolar proteins, shuttling between the nucleolus, nucleoplasm, and cytoplasm. Its diverse functions include rRNA transcription, processing, and ribosomal subunit assembly, making it essential for protein synthesis. In addition, nucleolin participates in mRNA stabilization, DNA repair, and chromatin remodeling.
Research using NCL antibody has shown that nucleolin plays crucial roles in cell proliferation and stress responses. Because of its involvement in ribosome production, nucleolin is highly expressed in rapidly dividing cells. In cancer, overexpression of NCL promotes tumor growth, angiogenesis, and resistance to apoptosis. Nucleolin interacts with oncogenic and tumor suppressor pathways, making it both a biomarker and potential therapeutic target.
In addition to cancer, nucleolin is implicated in viral infection, neurodegeneration, and cardiovascular disease. Viruses such as HIV and SARS-CoV-2 exploit nucleolin for entry or replication. In neurobiology, nucleolin regulates synaptic plasticity and neuronal survival under stress conditions. In cardiology, nucleolin modulates stress signaling pathways and contributes to vascular remodeling.
Nucleolin is also a target for therapeutic development. Aptamers, peptides, and small molecules targeting NCL are being explored in oncology and antiviral research. Monitoring NCL expression with antibodies helps evaluate disease progression and therapeutic efficacy.
Antibodies against nucleolin are validated for western blot, immunohistochemistry, immunofluorescence, and ELISA. These reagents provide robust detection across tissues and experimental systems. Clone-based NCL antibodies ensure specificity, supporting reproducible research outcomes.
NSJ Bioreagents provides this NCL antibody for studies in cancer, virology, and cellular stress biology. -
UniProt
- P19338
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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