MTA2 抗体
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北京 101111
Quick Overview for MTA2 抗体 (ABIN7881622)
抗原
See all MTA2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- MTA2 Antibody / Metastasis associated 1 family member 2
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纯化方法
- Affinity purified
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免疫原
- A synthetic peptide specific to human MTA2 was used as the immunogen for the MTA2 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the MTA2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the MTA2 antibody at -20oC.
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- MTA2 (Metastasis Associated 1 Family, Member 2 (MTA2))
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别名
- MTA2
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背景
- This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [RefSeq]
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UniProt
- O94776
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途径
- Chromatin Binding
抗原
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