Recombinant LFNG 抗体
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Quick Overview for Recombinant LFNG 抗体 (ABIN7881470)
抗原
See all LFNG 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- LFNG Antibody / Lunatic Fringe
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human Lunatic Fringe was used as the immunogen for the LFNG antibody.
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亚型
- IgG
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anti-LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG) (AA 1-250) antibody
LFNG 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2D10-3C11 unconjugated
anti-LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG) (AA 1-250) antibodyLFNG 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG) antibodyLFNG 适用: 人 WB, FACS, ICC 宿主: 兔 Monoclonal 23GB6595 unconjugated Recombinant Antibody
anti-LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG) (AA 86-114) antibodyLFNG 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB24078 unconjugated
anti-LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG) (AA 1-250) antibodyLFNG 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F9 unconjugated
anti-LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG) (Internal Region) antibodyLFNG 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG) (AA 74-123) antibodyLFNG 适用: 人, 小鼠, 大鼠, 豚鼠, Hamster, 猴, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG) (AA 93-122), (Middle Region) antibodyLFNG 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG) (AA 1-250) antibodyLFNG 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3C4 unconjugated
anti-LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG) (AA 1-125) antibodyLFNG 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B6 unconjugated
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应用备注
- Optimal dilution of the LFNG antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the LFNG antibody at -20oC.
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- LFNG (LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG))
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别名
- LFNG
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背景
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LFNG antibody detects lunatic fringe, a glycosyltransferase that modifies Notch receptors and regulates Notch signaling pathways. LFNG belongs to the fringe family of glycosyltransferases, which add N-acetylglucosamine residues to O-fucose on epidermal growth factor-like repeats of Notch. This modification alters ligand binding specificity and modulates signaling outcomes critical for development and tissue homeostasis.
Research using LFNG antibody has highlighted the protein's role in embryogenesis. LFNG is required for somitogenesis, the process that establishes segmented structures in the developing embryo. Loss of LFNG function leads to defects in somitic patterning and skeletal abnormalities, demonstrating its importance in developmental timing. Beyond embryonic segmentation, LFNG also contributes to hematopoiesis, vascular development, and neural differentiation by fine-tuning Notch signaling activity.
Dysregulation of LFNG has been implicated in cancer and congenital disorders. Aberrant expression of LFNG can lead to uncontrolled Notch signaling, a hallmark of various malignancies including breast cancer and T-cell acute lymphoblastic leukemia. Reduced LFNG activity may also contribute to congenital scoliosis and vertebral malformations. Understanding how LFNG modifies Notch receptors provides insights into therapeutic targeting of developmental and cancer-related pathways.
Antibodies against LFNG are validated for western blot, immunohistochemistry, and immunofluorescence. These tools enable researchers to study expression patterns in embryonic and adult tissues, as well as to evaluate changes in Notch pathway regulation. Clone-based antibodies ensure reliable detection of LFNG across experimental conditions.
NSJ Bioreagents provides this LFNG antibody for developmental biology, cancer, and signaling research. -
UniProt
- Q8NES3
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途径
- Notch Signaling
抗原
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