LGR5 抗体
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北京 101111
Quick Overview for LGR5 抗体 (ABIN7881466)
抗原
See all LGR5 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- GPR49 Antibody / LGR5
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纯化方法
- Affinity purified
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免疫原
- A synthetic peptide specific to human GPR49 / LGR5 was used as the immunogen for the GPR49 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the GPR49 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the GPR49 antibody at -20oC.
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- LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))
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别名
- GPR49
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背景
- G-protein coupled receptor 49,' or 'Leucine-rich repeat-containing G-protein coupled receptor 5' is a receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. [UniProt]
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UniProt
- O75473
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途径
- WNT signaling
抗原
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