IL-3 抗体
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北京 101111
Quick Overview for IL-3 抗体 (ABIN7881303)
抗原
See all IL-3 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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原理
- Interleukin 3 Antibody (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant protein fragment was used as the immunogen for the Interleukin 3 antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the Interleukin 3 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the Interleukin 3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- IL-3 (Interleukin 3 (IL-3))
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别名
- Interleukin 3
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背景
- Interleukin-3, or IL-3, is a pleiotropic cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL-3 not only supports growth of both pluripotent stem cells and the more differentiated committed progenitors, but it also stimulates the functional activity of some fully differentiated cells. IL-3 has also been shown to protect mast cells from undergoing apoptosis. IL-3 exerts its biological effects through a receptor which consists of a ligand-specific subunit has been shown to be necessary for activation of the MAP kinase signaling pathway. Although the IL-3 receptor has no intrinsic kinase activity, stimulation with IL-3 leads to tyrosine phosphorylation of the JAK/Tyk 2 family member, JAK2, which in turn activates and causes nuclear translocation of Stat5a and Stat5b.
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UniProt
- P08700
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途径
- JAK/STAT Signaling, Regulation of Carbohydrate Metabolic Process, Autophagy
抗原
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