IDE 抗体
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北京 101111
Quick Overview for IDE 抗体 (ABIN7881183)
抗原
See all IDE 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- IDE Antibody / Insulin degrading enzyme
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纯化方法
- Affinity purified
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免疫原
- A synthetic peptide specific to human Insulin-degrading enzyme / IDE was used as the immunogen for the IDE antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the IDE antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the IDE antibody at -20oC.
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- IDE (Insulin-Degrading Enzyme (IDE))
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别名
- IDE
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背景
- The IDE gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [RefSeq]
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UniProt
- P14735
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途径
- SARS-CoV-2 Protein Interactome
抗原
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