GRID2 抗体
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Quick Overview for GRID2 抗体 (ABIN7880884)
抗原
See all GRID2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- GRID2 Antibody
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序列
- KKDDEVFRTA VGDLNQN
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纯化方法
- Affinity purified
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免疫原
- Amino acids KKDDEVFRTAVGDLNQN from the human protein were used as the immunogen for the GRID2 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the GRID2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the GRID2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- GRID2 (Glutamate Receptor, Ionotropic, delta 2 (GRID2))
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别名
- GRID2
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背景
- Glutamate receptor, ionotropic, delta 2, also known as GluD2 and GluR delta 2, is a protein that in humans is encoded by the GRID2 gene. The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.
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UniProt
- O43424
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途径
- Synaptic Membrane
抗原
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