GRID2 抗体 (AA 831-880)
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Quick Overview for GRID2 抗体 (AA 831-880) (ABIN1534413)
抗原
See all GRID2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 831-880
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原理
- GluR-δ2 Antibody
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特异性
- GluR-δ2 Polyclonal Antibody detects endogenous levels of GluR-δ2 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human GRID2. AA range:831-880
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- GRID2 (Glutamate Receptor, Ionotropic, delta 2 (GRID2))
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别名
- GRID2
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背景
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Synonyms: GRID2; GLURD2; Glutamate receptor delta-2 subunit; GluR delta-2 subunit
Background: The protein encoded byThis gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this
Gene Name: GRID2
Protein Name: Glutamate receptor delta-2 subunit
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分子量
- 113 kDa
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基因ID
- 2895
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OMIM
- 602368
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UniProt
- O43424
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途径
- Synaptic Membrane
抗原
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