ERCC1 抗体
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北京 101111
Quick Overview for ERCC1 抗体 (ABIN7880754)
抗原
See all ERCC1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- ERCC1 Antibody
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纯化方法
- Affinity purified
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免疫原
- A synthetic peptide specific to human ERCC1 was used as the immunogen for the ERCC1 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the ERCC1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the ERCC1 antibody at -20oC.
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- ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))
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别名
- ERCC1
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背景
- The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. [RefSeq]
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UniProt
- P07992
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途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
抗原
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