Recombinant ERP27 抗体
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Quick Overview for Recombinant ERP27 抗体 (ABIN7880685)
抗原
See all ERP27 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- ERP27 Antibody / Endoplasmic reticulum resident protein 27 / TXNDC13
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human ERP27 was used as the immunogen for the ERP27 antibody.
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亚型
- IgG
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anti-Endoplasmic Reticulum Protein 27 (ERP27) (AA 1-273) antibody
ERP27 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Endoplasmic Reticulum Protein 27 (ERP27) (AA 26-273) antibodyERP27 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Endoplasmic Reticulum Protein 27 (ERP27) (AA 246-272), (C-Term) antibodyERP27 适用: 人 WB 宿主: 兔 Polyclonal RB37858 unconjugated
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应用备注
- Optimal dilution of the ERP27 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the ERP27 antibody at -20oC.
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- ERP27 (Endoplasmic Reticulum Protein 27 (ERP27))
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别名
- ERP27
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背景
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ERP27 antibody detects Endoplasmic reticulum resident protein 27, also called TXNDC13, encoded by the ERP27 gene. This protein belongs to the protein disulfide isomerase (PDI) family but is unique because it lacks catalytic cysteine residues required for disulfide bond formation. Instead, ERP27 functions as a non catalytic PDI family member that likely regulates protein folding through binding to unfolded substrates. ERP27 antibody provides a useful tool for studying protein folding, endoplasmic reticulum stress responses, and secretory pathway homeostasis.
Endoplasmic reticulum resident protein 27 is localized to the lumen of the endoplasmic reticulum, where it interacts with nascent polypeptides and folding intermediates. Although it lacks enzymatic activity, ERP27 binds to unfolded proteins, potentially presenting them to catalytic PDIs for isomerization. Research using ERP27 antibody has demonstrated that it contributes to quality control of protein folding, ensuring only properly folded proteins proceed through the secretory pathway. By acting as a chaperone like molecule, ERP27 complements enzymatic PDIs in maintaining proteostasis.
ERP27 is upregulated during conditions of endoplasmic reticulum stress, such as accumulation of unfolded proteins or perturbations in calcium homeostasis. Studies with ERP27 antibody have shown that its expression is regulated by the unfolded protein response, linking it to pathways that restore folding capacity and reduce stress. Dysregulation of ERP27 may contribute to diseases characterized by endoplasmic reticulum stress, including diabetes, neurodegeneration, and cancer. Understanding ERP27 expression and function helps clarify how cells cope with misfolded proteins and maintain secretory pathway fidelity.
In cancer, altered expression of endoplasmic reticulum chaperones influences tumor survival and progression. Research with ERP27 antibody has indicated that increased expression may provide tumor cells with resilience against proteotoxic stress, while reduced levels may impair secretory function. Its role in regulating folding efficiency positions ERP27 as an emerging factor in tumor biology and therapeutic resistance. Beyond cancer, ERP27 contributes to cellular stress adaptation across a wide range of tissues, including secretory cells of the pancreas and liver.
ERP27 antibody is widely applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting demonstrates induction under stress conditions, immunohistochemistry shows distribution in secretory tissues, and immunofluorescence confirms localization to the endoplasmic reticulum. These applications make ERP27 antibody valuable for research into protein folding, stress responses, and secretory pathway regulation.
By providing validated ERP27 antibody reagents, NSJ Bioreagents supports studies into protein folding, quality control, and disease. Detection of Endoplasmic reticulum resident protein 27 allows researchers to investigate how chaperone like proteins regulate proteostasis and contribute to pathology. -
UniProt
- Q96DN0
抗原
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