Recombinant Endoglin 抗体
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Quick Overview for Recombinant Endoglin 抗体 (ABIN7880681)
抗原
See all Endoglin (ENG) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- CD105 Antibody / Endoglin
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant fragment of human Endoglin protein was used as the immunogen for the CD105 antibody.
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亚型
- IgG, kappa
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应用备注
- Optimal dilution of the CD105 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the CD105 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Endoglin (ENG)
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别名
- CD105
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背景
- CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.
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UniProt
- P17813
抗原
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