Claudin 3 抗体
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北京 101111
Quick Overview for Claudin 3 抗体 (ABIN7880446)
抗原
See all Claudin 3 (CLDN3) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Claudin 3 Antibody / CLDN3
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序列
- RDKYAPTKIL YSAPRST
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纯化方法
- Affinity purified
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免疫原
- Amino acids RDKYAPTKILYSAPRST from the mouse protein were used as the immunogen for the Claudin 3 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the Claudin 3 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Claudin 3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Claudin 3 (CLDN3)
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别名
- Claudin 3
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背景
- Claudin 3, also known as CLDN3, is a protein which in humans is encoded by the CLDN3 gene. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a low-affinity receptor for clostridium perfringens enterotoxin (CPE) produced by the bacterium Clostridium perfringens, and the interaction with CPE results in increased membrane permeability by forming small pores in plasma membrane. This protein is highly overexpressed in uterine carcinosarcoma. This protein is also predominantly present in brain endothelial cells, where it plays a specific role in the establishment and maintenance of blood brain barrier tight junction morphology.
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UniProt
- Q9Z0G9
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途径
- Hepatitis C
抗原
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