CCR5 抗体
Our Local Distributor
北京 101111
Quick Overview for CCR5 抗体 (ABIN7880398)
抗原
See all CCR5 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- CCR5 Antibody
-
序列
- EKFRNYLLVF FQKHIAKRFC K
-
纯化方法
- Affinity purified
-
免疫原
- Amino acids EKFRNYLLVFFQKHIAKRFCK from the human protein were used as the immunogen for the CCR5 antibody.
-
亚型
- IgG
-
-
-
-
应用备注
- Optimal dilution of the CCR5 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the CCR5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
-
别名
- CCR5
-
背景
- C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines. It is mapped to 3p21.31. This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles, the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene.
-
UniProt
- P51681
-
途径
- Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size
抗原
-