CD3D 抗体
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北京 101111
Quick Overview for CD3D 抗体 (ABIN7880290)
抗原
See all CD3D 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- CD3D Antibody / CD3 delta
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纯化方法
- Affinity purified
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免疫原
- A synthetic peptide specific to human CD3D was used as the immunogen for the CD3D antibody.
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亚型
- IgG
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anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 127-171) antibody
CD3D 适用: 人 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 6B6B12 unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 127-171) antibodyCD3D 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 4B9G9 unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 22-105) antibodyCD3D 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 1F6A8 unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 127-171) antibodyCD3D 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1H12G5 unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 22-105) antibodyCD3D 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 18-113) antibodyCD3D 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 1-171) antibodyCD3D 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (Internal Region) antibodyCD3D 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) antibodyCD3D 适用: 人, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 22-104) antibodyCD3D 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the CD3D antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the CD3D antibody at -20oC.
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- CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))
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别名
- CD3D
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背景
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CD3D antibody recognizes CD3 delta subunit, a type I transmembrane protein encoded by the CD3D gene and commonly referred to as CD3 delta chain. CD3 delta is an essential component of the T cell receptor CD3 complex, which mediates antigen recognition and intracellular signaling in T lymphocytes. As part of the multimeric TCR-CD3 signaling complex, CD3 delta contributes to receptor assembly, membrane expression, and signal transduction required for adaptive immune responses. CD3D antibody supports research applications focused on T cell biology, immune signaling pathways, and lymphoid tissue characterization.
CD3 delta associates with CD3 gamma, CD3 epsilon, and CD3 zeta chains to form the invariant signaling module of the T cell receptor. Upon antigen engagement, immunoreceptor tyrosine-based activation motifs within the cytoplasmic domains of CD3 subunits undergo phosphorylation, triggering downstream signaling cascades that regulate T cell activation, proliferation, and cytokine production. CD3 delta localizes primarily to the plasma membrane of mature T cells, where it stabilizes receptor expression and contributes to immune synapse formation and signal amplification.
In normal human tissues, CD3 delta expression is restricted to T lymphocytes within thymus, lymph node, spleen, tonsil, and peripheral blood. Within lymphoid organs, CD3 staining highlights T cell-rich areas such as the paracortex of lymph nodes and interfollicular regions of tonsil, while B cell follicles and non-lymphoid stromal compartments remain largely negative. This lineage-specific distribution makes CD3D antibody a valuable marker for identifying T cell populations in research settings. Alterations in CD3 complex expression are relevant in studies of T cell immunodeficiencies and T cell leukemias or lymphomas, where receptor composition and signaling capacity may be disrupted.
Clone IDE-3 is a rabbit monoclonal antibody generated to recognize CD3 delta with defined specificity. CD3D antibody can be used to investigate T cell receptor signaling mechanisms, lymphoid architecture, and adaptive immune responses in experimental models. Its defined target recognition and membrane-associated staining profile support studies of T cell distribution and immune system function in normal and disease-associated tissues. -
UniProt
- P04234
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途径
- TCR Signaling, CXCR4-mediated Signaling Events
抗原
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