Cathepsin B 抗体
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北京 101111
Quick Overview for Cathepsin B 抗体 (ABIN7880201)
抗原
See all Cathepsin B (CTSB) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- CTSB Antibody / Cathepsin B
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纯化方法
- Affinity purified
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免疫原
- A synthetic peptide specific to human Cathepsin B / CTSB was used as the immunogen for the CTSB antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the CTSB antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the CTSB antibody at -20oC.
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- Cathepsin B (CTSB)
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别名
- CTSB
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背景
- The CTSB gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. [RefSeq]
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UniProt
- P07858
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途径
- Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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