Recombinant Caspase 6 抗体
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Quick Overview for Recombinant Caspase 6 抗体 (ABIN7880193)
抗原
See all Caspase 6 (CASP6) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- CASP6 Antibody / Caspase 6
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human Caspase-6 was used as the immunogen for the CASP6 antibody.
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亚型
- IgG
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anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (AA 194-293) antibody
CASP6 适用: Cow WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (AA 81-179) antibodyCASP6 适用: Cow WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (AA 194-293) antibodyCASP6 适用: 人 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 3B7E10 unconjugated
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (AA 24-44), (N-Term) antibodyCASP6 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (AA 7-27) antibodyCASP6 适用: 小鼠, 大鼠 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (AA 81-179) antibodyCASP6 适用: Cow WB, IHC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) antibodyKD Validated CASP6 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB1225 unconjugated Recombinant Antibody
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (AA 7-27), (N-Term) antibodyCASP6 适用: 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (AA 151-250) antibodyCASP6 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (N-Term) antibodyCASP6 适用: 人 WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the CASP6 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the CASP6 antibody at -20oC.
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- Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))
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别名
- CASP6
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背景
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CASP6 antibody detects caspase 6, a cysteine protease encoded by the CASP6 gene. Alternate identifiers include MCH2 and apoptotic cysteine protease 6. Caspase 6 belongs to the caspase family of cysteine aspartate proteases that orchestrate apoptosis and inflammation. Synthesized as an inactive proenzyme, caspase 6 undergoes autocatalytic processing or cleavage by upstream caspases to generate the active enzyme, which then cleaves specific substrates during programmed cell death.
CASP6 antibody is widely applied in neuroscience, apoptosis research, and oncology. Caspase 6 activity contributes to neuronal apoptosis and axonal degeneration, with elevated activity linked to Alzheimer disease and Huntington disease. In cancer biology, caspase 6 mediates apoptosis in response to stress and chemotherapeutic drugs. By detecting caspase 6, researchers can examine apoptotic pathways and their dysregulation in disease.
Western blot assays identify pro and cleaved caspase 6 isoforms, immunohistochemistry maps expression in tissues undergoing apoptosis, and immunofluorescence detects localization in neuronal and cancer cell models. These assays provide robust methods for analyzing apoptotic signaling pathways.
Caspase 6 cleaves substrates such as lamin A and huntingtin, contributing to nuclear disassembly and neurodegeneration. Dysregulated activity promotes pathological cell death, while insufficient activity may contribute to impaired apoptosis in cancer. By applying CASP6 antibody, scientists can evaluate the balance of pro survival and pro death signals across systems.
CASP6 antibody from NSJ Bioreagents delivers reliable specificity for detecting caspase 6. Its performance across multiple applications supports both basic apoptosis research and translational studies in oncology and neurodegeneration. -
UniProt
- P55212
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途径
- Apoptosis, Caspase Cascade in Apoptosis
抗原
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