PUMA 抗体
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北京 101111
Quick Overview for PUMA 抗体 (ABIN7880054)
抗原
See all PUMA (BBC3) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- PUMA Antibody (alpha/beta) / BBC3
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序列
- EQWAREIGAQ LRRMADDLNA QYE
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纯化方法
- Antigen affinity purified
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免疫原
- Amino acids EQWAREIGAQLRRMADDLNAQYE were used as the immunogen for the PUMA antibody.
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亚型
- IgG
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anti-BCL2 Binding Component 3 (BBC3) (AA 131-180) antibody
BBC3 适用: 人, 大鼠, Pig WB, ELISA, IP, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (AA 119-154) antibodyBBC3 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (AA 119-154) antibodyBBC3 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB01353 unconjugated
anti-BCL2 Binding Component 3 (BBC3) (BH3 Domain), (C-Term) antibodyBBC3 适用: 人, 小鼠 WB, IF, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (N-Term) antibodyBBC3 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (AA 98-152) antibodyBBC3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5D10 unconjugated
anti-BCL2 Binding Component 3 (BBC3) (C-Term) antibodyBBC3 适用: 人, 小鼠 WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (AA 186-199) antibodyBBC3 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (AA 2-16) antibodyBBC3 适用: 人, 大鼠, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) antibodyBBC3 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB1935 unconjugated Recombinant Antibody
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应用备注
- Optimal dilution of the PUMA antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PUMA antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))
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别名
- PUMA
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背景
- Bcl-2-binding component 3, isoforms 1/2 (BBC3), also called p53 upregulated modulator of apoptosis (PUMA), is a pro-apoptotic member of the Bcl-2 protein family. The gene is located at 19q. The transcript is contained within 4 exons, with the presumptive initiation codon in exon 2. The predicted 193-amino acid PUMA protein shares 91 % amino acid identity with the murine sequence. Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of PUMA is regulated by the tumor suppressor p53, and the protein has been shown to be involved in p53-mediated apoptosis. Additionally, PUMA encodes two BH3 domain-containing proteins, PUMA-alpha and PUMA-beta, that are produced through the use of an alternative first exon and are induced in cells following p53 activation. Furthermore, PUMA couples the nuclear and cytoplasmic proapoptotic functions of p53.
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UniProt
- Q9BXH1
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途径
- p53 Pathway, Positive Regulation of Endopeptidase Activity
抗原
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