ALDH2 抗体
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北京 101111
Quick Overview for ALDH2 抗体 (ABIN7879940)
抗原
See all ALDH2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- ALDH2 Antibody / Aldehyde dehydrogenase 2
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纯化方法
- Affinity purified
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免疫原
- A synthetic peptide specific to human ALDH2 was used as the immunogen for the ALDH2 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the ALDH2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the ALDH2 antibody at -20oC.
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- ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2))
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别名
- ALDH2
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背景
- This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50 % of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [RefSeq]
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UniProt
- P05091
抗原
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