ALDH2 抗体
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Quick Overview for ALDH2 抗体 (ABIN7879939)
抗原
See all ALDH2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- ALDH2 Antibody
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序列
- SAAATQAVPA PNQQPEVFCN QIFINNEWHD A
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纯化方法
- Affinity purified
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免疫原
- Amino acids SAAATQAVPAPNQQPEVFCNQIFINNEWHDA were used as the immunogen for the ALDH2 antibody.
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亚型
- IgG2a
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应用备注
- Optimal dilution of the ALDH2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the ALDH2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2))
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别名
- ALDH2
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背景
- ALDH2 (Aldehyde Dehydrogenase 2 Family) is a human gene. The enzyme encoded by this gene belongs to the aldehyde dehydrogenase family of enzymes that catalyze the chemical transformation from acetaldehyde to acetic acid. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Hsu et al. (1985) assigned the ALDH2 locus to chromosome 12 by means of a cDNA probe and Southern blot analysis of somatic cell hybrids. Using an unbiased proteomic search, Chen et al. (2008) identified mitochondrial ALDH2 as an enzyme whose activation correlated with reduced ischemic heart damage in rodent models. A high-throughput screen identified a small molecule activator of ALDH2, which they called Alda-1, that, when administered to rats before an ischemic event, reduced infarct size by 60 % , most likely through its inhibitory effect on the formation of cytotoxic aldehydes.
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UniProt
- P05091
抗原
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