CTNND1 抗体 (pTyr96)
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北京 101111
Quick Overview for CTNND1 抗体 (pTyr96) (ABIN7879842)
抗原
See all CTNND1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pTyr96
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原理
- p120 Catenin Antibody (pTyr96) / CTNND1 / Catenin delta 1
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纯化方法
- Protein G affinity chromatography
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免疫原
- The amino acid sequence surrounding phosphorylated Tyr96 was used as the immunogen for the p120 Catenin antibody.
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亚型
- IgG1, kappa
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anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) antibody
CTNND1 适用: 人 WB, IHC, IP 宿主: 兔 Monoclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (AA 573-832) antibodyCTNND1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) antibodyKD Validated CTNND1 适用: 人 WB, IF (p), FACS 宿主: 兔 Monoclonal 23GB3025 unconjugated Recombinant Antibody
anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) antibodyKD Validated CTNND1 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 24GB5775 unconjugated
anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) antibodyCTNND1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (AA 64-930) antibodyCTNND1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (AA 64-930) antibodyCTNND1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal 8G7E4 unconjugated
anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) antibodyCTNND1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (Tyr228) antibodyCTNND1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (AA 482-605) antibodyCTNND1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the p120 Catenin antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the p120 Catenin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))
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别名
- p120 Catenin
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背景
- The membrane associated protein pp120 Src substrate (p120 Catenin, p120cas) was identified as a tyrosine kinase substrate that is phosphorylated in Src transformed cells or in response to growth factor stimulation. It shares structural similarity with the Drosophila Armadillo protein and the vertebrate beta-catenin and gamma-catenin proteins. Its characteristic Arm domain that is composed of 42-amino acid motif repeats evidences this similarity. In the cell, p120 Catenin is localized to the E-Cadherin/catenins cell adhesion complex. Like beta- and gamma-catenin, p120 Catenin directly associates with the cytoplasmic C-terminus of E-Cadherin via its Arm domain and may similarly interact with other Cadherins. It exists as four isoforms that range in size from 90-115 kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered pp120 expression contributes to malignancy due to loss of functional cell adhesions. Multiple tyrosine residues (Y96, Y112, Y228, Y280, Y257, Y291, Y296, and Y302) in p120 Catenin are phosphorylated by Src and these phosphorylations may facilitate interaction with PTP1C/SHP-1 in response to EGF stimulation. Thus, p120 Catenin is an Arm domain protein that interacts with both cell adhesion molecules, such as cadherins and cell signaling molecules, such as PTP1C.
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UniProt
- O60716
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途径
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling
抗原
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