Recombinant BCAR1 抗体 (pTyr410)
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Quick Overview for Recombinant BCAR1 抗体 (pTyr410) (ABIN7879834)
抗原
See all BCAR1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pTyr410
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原理
- Phospho-BCAR1 (Tyr410) Antibody / Breast cancer anti-estrogen resistance protein 1
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human Phospho-BCAR1 (Y410) was used as the immunogen for the Phospho-BCAR1 (Tyr410) antibody.
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亚型
- IgG
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anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) (AA 1-240) antibody
BCAR1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) antibodyBCAR1 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC, IF, IHC (p), FACS 宿主: 小鼠 Monoclonal 3A5 unconjugated
anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) antibodyBCAR1 适用: 人, 大鼠, 犬, 猴 WB, IHC, IF, IHC (p), FACS 宿主: 小鼠 Monoclonal 1B1 unconjugated
anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) (pTyr410) antibodyBCAR1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) (AA 68-218) antibodyBCAR1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) (Internal Region) antibodyBCAR1 适用: 人, 小鼠 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) (Tyr410) antibodyBCAR1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) (pTyr410) antibodyKD Validated BCAR1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB3870 unconjugated Recombinant Antibody
anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) antibodyKD Validated BCAR1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB3690 unconjugated Recombinant Antibody
anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) (AA 1-870) antibodyBCAR1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Phospho-BCAR1 (Tyr410) antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the Phospho-BCAR1 (Tyr410) antibody at -20oC.
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- BCAR1 (Breast Cancer Anti-Estrogen Resistance 1 (BCAR1))
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别名
- BCAR1
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背景
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Phospho-BCAR1 (Tyr410) antibody detects breast cancer anti-estrogen resistance protein 1 when phosphorylated at tyrosine 410. BCAR1, also known as p130Cas, is an adaptor protein encoded by the BCAR1 gene. It localizes to focal adhesions where it links integrins and growth factor receptors to downstream signaling pathways. Phosphorylation at Tyr410 is a critical event that promotes protein protein interactions and assembly of signaling complexes regulating adhesion, migration, and survival.
Phospho-BCAR1 (Tyr410) antibody is widely used to study integrin signaling, cytoskeletal dynamics, and cancer biology. BCAR1 phosphorylation at focal adhesions enables activation of Src family kinases and downstream effectors such as Rac and JNK. By detecting the phosphorylated form of BCAR1, this antibody provides insight into how cells sense and respond to extracellular matrix cues.
The antibody is suitable for western blotting, immunohistochemistry, and immunofluorescence. In western blot assays, Phospho-BCAR1 (Tyr410) antibody detects phosphorylated isoforms distinct from non phosphorylated protein. Immunohistochemistry maps phosphorylation events in tissue samples, while immunofluorescence reveals spatial localization of activated BCAR1 at focal adhesions. These approaches allow researchers to monitor cell adhesion signaling with high precision.
BCAR1 phosphorylation has been linked to oncogenesis and therapy resistance. Elevated phospho BCAR1 levels are associated with enhanced tumor invasion and poor prognosis in breast and other cancers. By using Phospho-BCAR1 (Tyr410) antibody, scientists can evaluate how dysregulated adhesion signaling contributes to malignancy and whether Tyr410 phosphorylation serves as a biomarker of tumor progression.
Beyond oncology, BCAR1 phosphorylation plays roles in cardiovascular and immune systems. It regulates endothelial cell migration during angiogenesis and contributes to immune cell trafficking. In developmental contexts, BCAR1 activity is essential for morphogenesis and tissue patterning. The phospho specific antibody enables detailed investigation of these roles across models.
Phospho-BCAR1 (Tyr410) antibody from NSJ Bioreagents provides strong specificity for activated BCAR1, supporting studies of integrin signaling, migration, and cancer biology. Its proven reliability ensures accurate detection of phosphorylation events in multiple research applications. -
UniProt
- P56945
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途径
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling
抗原
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