Recombinant RPS6KB2 抗体 (pSer371)
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Quick Overview for Recombinant RPS6KB2 抗体 (pSer371) (ABIN7879759)
抗原
See all RPS6KB2 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pSer371
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原理
- Phospho-p70 S6 Kinase beta (Ser371) Antibody
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human Phospho-P70 S6 Kinase beta (S371) was used as the immunogen for the Phospho-p70 S6 Kinase beta (Ser371) antibody.
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亚型
- IgG
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anti-Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2) antibody
RPS6KB2 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2) antibodyKD Validated RPS6KB2 适用: 人 WB, FACS, IF (p), ICC 宿主: 兔 Monoclonal 24GB1235 unconjugated Recombinant Antibody
anti-Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2) (AA 1-482) antibodyRPS6KB2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2) (AA 1-100) antibodyRPS6KB2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4B11 unconjugated
anti-Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2) antibodyRPS6KB2 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2) antibodyRPS6KB2 适用: 人, 小鼠 WB, ELISA 宿主: 小鼠 Monoclonal 164CT21-2-2 unconjugated
anti-Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2) antibodyRPS6KB2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22726 unconjugated
anti-Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2) (Center) antibodyRPS6KB2 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2) (Center) antibodyRPS6KB2 适用: 人, 小鼠 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2) antibodyKD Validated RPS6KB2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB5075 unconjugated Recombinant Antibody
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应用备注
- Optimal dilution of the Phospho-p70 S6 Kinase beta (Ser371) antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the Phospho-p70 S6 Kinase beta (Ser371) antibody at -20oC.
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- RPS6KB2 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2))
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别名
- p70 S6 Kinase beta
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背景
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Phospho-p70 S6 Kinase beta (Ser371) antibody detects the phosphorylated form of ribosomal protein S6 kinase beta-1 (S6K1) at serine 371. S6K1, also called p70S6K, is a serine/threonine kinase activated downstream of mTORC1 and plays a pivotal role in protein synthesis, cell growth, and metabolism. Phosphorylation at Ser371 is an essential priming event for full kinase activation, enabling subsequent phosphorylation at the hydrophobic motif and activation loop.
Research using Phospho-p70 S6 Kinase beta (Ser371) antibody highlights the importance of this modification in cell growth and proliferation. Ser371 phosphorylation enhances kinase activity, promoting phosphorylation of ribosomal protein S6 and translation initiation factors. This activity stimulates protein synthesis, supporting anabolic metabolism and cellular hypertrophy. In cancer, aberrant activation of S6K1 contributes to uncontrolled growth and resistance to apoptosis. Elevated Ser371 phosphorylation has been observed in breast, prostate, and colorectal tumors, where it correlates with mTORC1 hyperactivation.
Phosphorylation at Ser371 is also a readout of nutrient and growth factor signaling. Under nutrient-rich conditions, mTORC1 activity drives S6K1 phosphorylation, whereas nutrient deprivation or rapamycin treatment diminishes this event. Monitoring Ser371 phosphorylation provides insight into mTOR pathway regulation in metabolic disease and therapeutic interventions. In insulin resistance and type 2 diabetes, dysregulated S6K1 signaling contributes to feedback inhibition of insulin receptor substrates, linking it to impaired glucose homeostasis.
Neurobiology studies show that S6K1 activity influences synaptic plasticity, memory, and neuronal survival. Ser371 phosphorylation may integrate mTOR activity with cognitive functions, while dysregulation is implicated in neurodegenerative disorders. In cardiovascular research, hyperactivation of S6K1 contributes to pathological hypertrophy and vascular remodeling.
Antibodies against phospho-S6K1 (Ser371) are validated for western blot, immunohistochemistry, and immunofluorescence. These reagents specifically recognize the phosphorylated form, enabling distinction between active and inactive states. Clone-based antibodies provide reproducibility for studying signaling pathways, drug responses, and disease mechanisms.
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UniProt
- Q9UBS0
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途径
- PI3K-Akt Signaling, RTK signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
抗原
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