Recombinant MAP2 抗体 (pSer136)
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北京 101111
Quick Overview for Recombinant MAP2 抗体 (pSer136) (ABIN7879708)
抗原
See all MAP2 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pSer136
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原理
- Phospho-MAP2 (Ser136) Antibody / Microtubule-associated protein 2
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human Phospho-MAP2 (S136) was used as the immunogen for the Phospho-MAP2 (Ser136) antibody.
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亚型
- IgG
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anti-Microtubule-Associated Protein 2 (MAP2) antibody
MAP2 适用: 人, 小鼠, Pig WB, ELISA, ICC, IP, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal MT-08 unconjugated
anti-Microtubule-Associated Protein 2 (MAP2) (AA 260-559) antibodyMAP2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 2 (MAP2) antibodyMAP2 适用: Cow WB, IHC, ELISA, ICC 宿主: 小鸡 Polyclonal unconjugated
anti-Microtubule-Associated Protein 2 (MAP2) (N-Term) antibodyMAP2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 2 (MAP2) antibodyMicroarray verified MAP2 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB573626 unconjugated
anti-Microtubule-Associated Protein 2 (MAP2) antibodyMAP2 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 小鼠 Monoclonal unconjugated
anti-Microtubule-Associated Protein 2 (MAP2) antibodyMAP2 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 159CT34-12-3-4 unconjugated
anti-Microtubule-Associated Protein 2 (MAP2) (AA 1459-1718) antibodyMAP2 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 2 (MAP2) (AA 727-985) antibodyMAP2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 2 (MAP2) antibodyMAP2 适用: 人, 小鼠, 大鼠, 兔 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 5F9 unconjugated
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应用备注
- Optimal dilution of the Phospho-MAP2 (Ser136) antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the Phospho-MAP2 (Ser136) antibody at -20oC.
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- MAP2 (Microtubule-Associated Protein 2 (MAP2))
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别名
- MAP2
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背景
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Phospho-MAP2 (Ser136) antibody detects microtubule-associated protein 2 (MAP2) when phosphorylated at serine 136. MAP2 is a neuronal cytoskeletal protein that stabilizes microtubules and contributes to dendritic architecture, synaptic plasticity, and neuronal signaling. Phosphorylation at Ser136, mediated by kinases such as PKA and CaMKII, modulates MAP2's ability to bind microtubules and regulate cytoskeletal dynamics.
Research using Phospho-MAP2 (Ser136) antibody has demonstrated its importance in neuronal development and function. Phosphorylation at Ser136 reduces MAP2's affinity for microtubules, promoting reorganization of dendritic structures. This regulation is critical during synaptogenesis, axon guidance, and activity-dependent plasticity. In models of learning and memory, changes in Ser136 phosphorylation correlate with synaptic remodeling and behavioral adaptation.
In neurodegenerative disease, dysregulated MAP2 phosphorylation contributes to cytoskeletal instability and neuronal dysfunction. Aberrant phosphorylation patterns are observed in Alzheimer's disease, Parkinson's disease, and traumatic brain injury, where MAP2 loss or mislocalization signals neuronal damage. Monitoring Ser136 phosphorylation provides insights into neuronal health and disease progression.
MAP2 phosphorylation also influences interactions with signaling molecules and cytoskeletal regulators. By modulating dendritic morphology, phospho-MAP2 contributes to long-term potentiation and depression, essential processes underlying cognition. Altered Ser136 phosphorylation has been linked to psychiatric conditions, including schizophrenia and depression, where synaptic dysfunction is a hallmark.
Antibodies against phospho-MAP2 (Ser136) are validated for immunohistochemistry, immunofluorescence, and western blot. These reagents selectively detect the phosphorylated form, distinguishing it from total MAP2. Clone-based antibodies ensure reproducibility and specificity in complex neuronal systems.
NSJ Bioreagents supplies this Phospho-MAP2 (Ser136) antibody for studies in neurodevelopment, synaptic plasticity, and neurodegenerative disease. -
UniProt
- P11137
抗原
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