Recombinant p40 (p63 Delta) (N-Term) 抗体
This 兔 单克隆 antibody specifically detects p40 (p63 Delta) in FACS, IF 和 IHC (p). It exhibits reactivity toward 人.
产品编号 ABIN7879640
发货至:
中国
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Quick Overview for Recombinant p40 (p63 Delta) (N-Term) 抗体 (ABIN7879640)
抗原
p40 (p63 Delta)
抗体类型
Recombinant Antibody
适用
人
宿主
兔
克隆类型
单克隆
标记
非结合性
应用范围
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
质量等级
Carrier-free
克隆位点
TP40-3980R
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抗原表位
- N-Term
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原理
- Recombinant p40 Antibody / deltaNp63 (azide and preservative free)
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纯化方法
- Protein A affinity chromatography
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免疫原
- A synthetic peptide from the N-terminal of human p40 protein was used as the immunogen for the p40 antibody.
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亚型
- IgG
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anti-p40 (p63 Delta) (AA 1-50) antibody
适用: 人 IHC, WB 宿主: 小鼠 Monoclonal BC28 unconjugated
anti-p40 (p63 Delta) (AA 5-17) antibodyCarrier-free 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the recombinant p40 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the recombinant p40 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- p40 (p63 Delta)
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别名
- p40
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背景
- P63 consists of two major isoforms-TAp63 and delta-Np63. These isoforms differ in the structure of the N-terminal domains. The TAp63 isoform (identified by anti-p63 antibody) contains a transactivation-competent TA domain with homology to p53, which regulates the expression of the growth-inhibitory genes. In contrast, DNp63 isoform (identified by anti-p40 antibody) contains an alternative transcriptionally-inactive delta-N domain, which antagonizes the activity of TAp63 and p53. P40/3980R recognizes exclusively delta-Np63 but not TAp63. p40 is a squamous cell carcinoma specific antibody. It reacts with the vast majority of cases of squamous cell carcinomas of various origins, but not with adenocarcinomas. It is particularly useful in differentiating lung squamous cell carcinoma from lung poorly differentiated adenocarcinoma. p40 antibody can also be used as an alternative basal cell/myoepithelial cell marker, which has similar sensitivity and specificity as that of p63 antibody. Therefore, p40 antibody may also be used as an alternative immunohistochemical marker for determining prostate adenocarcinoma vs. benign prostate glands and for determining breast intraductal carcinoma vs. invasive breast ductal carcinoma.
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UniProt
- Q9H3D4
抗原
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