Recombinant p40 (p63 Delta) (AA 1-200) 抗体
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Quick Overview for Recombinant p40 (p63 Delta) (AA 1-200) 抗体 (ABIN7863563)
抗原
抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-200
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原理
- Recombinant p40 (Squamous, Basal & Myoepithelial Cell Marker) Antibody
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特异性
- P63 is a homolog of the tumor suppressor p53. It is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63 was detected in nuclei of the basal epithelium in normal prostate glands, however, it was not expressed in malignant tumors of the prostate. As a result, p63 has been reported as a useful marker for differentiating benign from malignant lesions in the prostate, particularly when used in combination with markers of high molecular weight cytokeratins and the prostate-specific marker AMACR (P504S). p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with a sensitivity of ~90 % . Specificity for lung SqCC, vs. lung adenocarcinoma (LADC), is approximately 80 %. In breast tissue, p63 has been identified in myoepithelial cells of normal ducts.
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纯化方法
- 200ug/ml of Ab purified by Protein A Column.
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免疫原
- Recombinant fragment (around aa1-200) of human TP63 protein (exact sequence is proprietary)
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亚型
- IgG, kappa
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anti-p40 (p63 Delta) (AA 1-50) antibody
适用: 人 IHC, WB 宿主: 小鼠 Monoclonal BC28 unconjugated
anti-p40 (p63 Delta) (AA 5-17) antibody适用: 人, Cow, 小鼠, 大鼠 FACS, WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- p40 (p63 Delta)
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别名
- p40
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背景
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Amplified in squamous cell carcinoma (AIS), Chronic ulcerative stomatitis protein (CUSP), EEC3, Keratinocyte transcription factor KET, LMS, NBP, p40, P51/P63, p53 like transcription factor, p53-related protein p63, RHS, SHFM4, TAp63alpha, TP53CP, TP53L, TP63, TP73, TP73L, Transformation-related protein 63, Trp53rp1, Trp6,3
HEK293, lung or bladder squamous cell carcinoma tissue., MDA-MB453 or MCF7 cells. Human prostate
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分子量
- 63kDa
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基因ID
- 8626, 137569
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UniProt
- Q9H3D4
抗原
-
