Recombinant p40 (p63 Delta) (AA 1-200) 抗体
The 兔 单克隆 anti-p40 (p63 Delta) antibody is suitable to detect p40 (p63 Delta) in samples from 人. It has been validated for IHC.
产品编号 ABIN7864324
发货至:
中国
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Quick Overview for Recombinant p40 (p63 Delta) (AA 1-200) 抗体 (ABIN7864324)
抗原
p40 (p63 Delta)
抗体类型
Recombinant Antibody
适用
人
宿主
兔
克隆类型
单克隆
标记
非结合性
应用范围
Immunohistochemistry (IHC)
克隆位点
P40-8225R
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抗原表位
- AA 1-200
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原理
- Recombinant p40 (deltaNp63) (Squamous, Basal & Myoepithelial Cell Marker) Antibody
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特异性
- P63 consists of two major isoforms-TAp63 and delta-Np63. These isoforms differ in the structure of the N-terminal domains. The TAp63 isoform (identified by anti-p63 antibody) contains a transactivation-competent TA domain with homology to p53, which regulates the expression of the growth-inhibitory genes. In contrast, DNp63 isoform (identified by anti-p40 antibody) contains an alternative transcriptionally-inactive delta-N domain, which antagonizes the activity of TAp63 and p53. The p40 (clone P40/8225R) antibody recognizes exclusively delta-Np63 but not TAp63. p40 is a squamous cell carcinoma specific antibody. It reacts with the vast majority of cases of squamous cell carcinomas of various origins, but not with adenocarcinomas. It is particularly useful in differentiating lung squamous cell carcinoma from lung poorly differentiated adenocarcinoma. p40 antibody can also be used as an alternative basal cell/myoepithelial cell marker, which has similar sensitivity and specificity as that of p63 antibody. Therefore, p40 antibody may also be used as an alternative immunohistochemical marker for determining prostate adenocarcinoma vs. benign prostate glands and for determining breast intraductal carcinoma vs. invasive breast ductal carcinoma.
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纯化方法
- 200ug/ml of Ab purified by Protein A Column.
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免疫原
- Recombinant fragment (around aa1-200) of human TP63 protein (exact sequence is proprietary)
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亚型
- IgG, kappa
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anti-p40 (p63 Delta) (AA 1-50) antibody
适用: 人 IHC, WB 宿主: 小鼠 Monoclonal BC28 unconjugated
anti-p40 (p63 Delta) (AA 5-17) antibody适用: 人, Cow, 小鼠, 大鼠 FACS, WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- p40 (p63 Delta)
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别名
- p40
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背景
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deltaNp63, TP63
HeLa cells. Human prostate or lung tissue (IHC).
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分子量
- 40kDa
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基因ID
- 8626, 137569
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UniProt
- Q9H3D4
抗原
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