APOBEC3C 抗体 (N-Term)
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Quick Overview for APOBEC3C 抗体 (N-Term) (ABIN7879561)
抗原
See all APOBEC3C 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- APOBEC3C Antibody
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纯化方法
- Immunogen affinity purified
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human APOBEC3C was used as the immunogen for the APOBEC3C antibody.
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亚型
- IgG
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anti-Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C) (Center) antibody
APOBEC3C 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C) (AA 91-190) antibodyAPOBEC3C 适用: 人 ELISA, IP 宿主: 小鼠 Monoclonal 3E6 unconjugated
anti-Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C) (AA 1-190) antibodyAPOBEC3C 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C) (C-Term) antibodyVerified APOBEC3C 适用: 人 WB, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C) antibodyAPOBEC3C 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C) (AA 1-190) antibodyAPOBEC3C 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C) (AA 1-190) antibodyAPOBEC3C 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C) (AA 1-190) antibodyAPOBEC3C 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C) (AA 143-177) antibodyAPOBEC3C 适用: 人 WB 宿主: 兔 Polyclonal RB56223 unconjugated
anti-Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C) (AA 1-190) antibodyAPOBEC3C 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal dilution of the APOBEC3C antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the APOBEC3C antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- APOBEC3C (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C))
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别名
- APOBEC3C
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背景
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APOBEC3C antibody detects DNA dC-to-dU-editing enzyme APOBEC-3C, a cytidine deaminase involved in antiviral defense, DNA mutagenesis, and innate immune regulation. Encoded by the APOBEC3C gene on chromosome 22q13.1, this enzyme belongs to the APOBEC3 subfamily of cytidine deaminases, which act by deaminating cytidine to uridine in single-stranded DNA. APOBEC3C plays a central role in restricting viral replication, particularly retroviruses and retrotransposons, through cytidine deamination and interference with reverse transcription.
Structurally, APOBEC3C contains a single catalytic zinc-dependent deaminase domain characterized by the H-X-E-X(23-28)-P-C-X2-C motif, which coordinates zinc ions for catalytic activity. It primarily targets cytosines within the 5'-TC context of viral DNA, leading to G-to-A hypermutations that inhibit viral genome integrity. APOBEC3C acts against human immunodeficiency virus type 1 (HIV-1) and other retroelements by editing viral cDNA during replication. Its antiviral activity is antagonized by viral infectivity factor (Vif) proteins that mediate APOBEC degradation via the ubiquitin-proteasome pathway.
The APOBEC3C antibody is used in virology, immunology, and genomic stability research to study intrinsic antiviral immunity and cytidine deamination mechanisms. Western blot analysis detects a 23 kilodalton band corresponding to APOBEC3C, while immunofluorescence shows cytoplasmic and nuclear localization depending on infection or stress conditions. This antibody supports the investigation of APOBEC3C-mediated mutagenesis, viral restriction, and immune regulation.
Beyond antiviral defense, APOBEC3C influences genomic diversity and cancer mutagenesis by contributing to localized DNA editing events. Dysregulation or overexpression of APOBEC family enzymes, including APOBEC3C, has been linked to mutational signatures in various cancers. The APOBEC3C antibody provides a reliable tool for exploring the dual roles of APOBEC3C in immunity and genome evolution. NSJ Bioreagents offers this antibody validated for western blotting, immunohistochemistry, and immunofluorescence, ensuring robust and reproducible detection in studies of antiviral defense and mutation biology. -
UniProt
- Q9NRW3
抗原
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