PAK4/PAK5/PAK6 (pSer560) 抗体 (FITC)
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北京 101111
Quick Overview for PAK4/PAK5/PAK6 (pSer560) 抗体 (FITC) (ABIN744480)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer560
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic phosphopeptide derived from human PAK4 around the phosphorylation site of PAK4 Ser474 [RK(p-S)LV]
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亚型
- IgG
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anti-PAK4/PAK5/PAK6 (pSer474), (pSer560), (pSer602) antibody
适用: 人 WB, FACS, ICC 宿主: 兔 Monoclonal 24GB445 unconjugated Recombinant Antibody
anti-PAK4/PAK5/PAK6 (pSer474), (pSer560), (pSer602) antibody适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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应用备注
- IF(IHC-P)(1:50-200)
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- PAK4/PAK5/PAK6
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Sub Type
- Cocktail
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背景
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Synonyms: PAK4Ser474, PAK5Ser602, PAK6Ser560, p21 activated kinase 4 , p21CDKN1A activated kinase 4, PAK 4, Protein kinase related to S.cerevisiae STE20 effector for Cdc42Hs, Serine threonine kinase PAK 4, Serine/threonine protein kinase PAK 4, Serine/threonine protein kinase PAK4, KIAA1142, PAK4_HUMAN.
Background: p21-activated kinases (PAKs) belong to the family of serine/threonine kinases involved in the control of various cellular processes, including the cell cycle, dynamics of the cytoskeleton, apoptosis, oncogenic transformation, and transcription. All PAK family members are characterized by the presence of p21-binding domain. p21-activated kinases are regulated by the small GTP-binding proteins Rac and Cdc42, and lipids, which stimulate autophosphorylation and phosphorylation of exogenous substrates. Serine (Ser-474) is the likely autophosphorylation site in the kinase domain of PAK4 in vivo. Phosphospecific directed against serine 474 detect activated PAK4 on the Golgi membrane when PAK4 is co-expressed with activated Cdc42. Current data strongly implicates PAK-4 in oncogenesis. PAK4 is frequently overexpressed in human tumor cell lines of various tissue origins.
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基因ID
- 10298
抗原
-
