OSTM1 抗体 (Middle Region)
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Quick Overview for OSTM1 抗体 (Middle Region) (ABIN7879535)
抗原
See all OSTM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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原理
- OSTM1 Antibody / Osteopetrosis-associated transmembrane protein 1
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纯化方法
- Immunogen affinity purified
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human OSTM1 was used as the immunogen for the OSTM1 antibody.
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亚型
- IgG
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anti-Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) (AA 21-120) antibody
OSTM1 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) (AA 183-282) antibodyOSTM1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4H1 unconjugated
anti-Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) (AA 124-277) antibodyOSTM1 适用: 大鼠 WB, IP, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) (AA 32-284) antibodyOSTM1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) (AA 1-334) antibodyOSTM1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) (AA 292-321), (C-Term) antibodyOSTM1 适用: 人 WB 宿主: 兔 Polyclonal RB33416 unconjugated
anti-Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) (AA 120-251) antibodyOSTM1 适用: 人 WB, IP, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the OSTM1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the OSTM1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- OSTM1 (Osteopetrosis Associated Transmembrane Protein 1 (OSTM1))
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别名
- OSTM1
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背景
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OSTM1 antibody detects Osteopetrosis-associated transmembrane protein 1, a lysosomal membrane protein essential for osteoclast function and bone resorption. Encoded by the OSTM1 gene on chromosome 6q21, this protein forms a complex with the chloride channel CLCN7, stabilizing its localization and activity within lysosomal and ruffled-border membranes. The OSTM1-CLCN7 complex is critical for acidification and ion exchange in osteoclasts, processes that drive bone matrix degradation and remodeling. Loss of OSTM1 function results in autosomal recessive osteopetrosis, characterized by dense but brittle bones and defective osteoclast activity.
OSTM1 contains a single transmembrane domain and a large luminal glycoprotein region that protects lysosomal membranes from degradation. It plays a dual role as a chaperone for CLCN7 and as a structural component of lysosomal and endosomal membranes. In addition to skeletal tissues, OSTM1 is expressed in neurons and immune cells, where it contributes to lysosomal biogenesis and degradation of cellular material. Its deficiency leads to impaired lysosomal trafficking, abnormal autophagy, and neurodegeneration.
The OSTM1 antibody is widely used in bone biology, lysosomal function, and neurodegeneration research to study protein trafficking, osteoclast activity, and lysosomal integrity. Western blot analysis identifies a 40-50 kilodalton band corresponding to glycosylated OSTM1, while immunofluorescence reveals punctate lysosomal localization that colocalizes with LAMP1 and CLCN7. This antibody supports detailed studies of lysosomal acidification, bone remodeling, and cellular degradation pathways.
Beyond osteoclast biology, OSTM1 influences autophagic flux and neuronal survival through regulation of lysosomal enzyme maturation and pH balance. The OSTM1 antibody provides an effective tool for exploring the cellular mechanisms underlying osteopetrosis, lysosomal storage disorders, and neurodegenerative diseases. NSJ Bioreagents offers this antibody validated for its applications, ensuring high specificity and reproducibility in lysosomal research. -
UniProt
- Q86WC4
抗原
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