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Histone H2A 抗体 (H2AS139ph)

The 小鼠 单克隆 anti-Histone H2A antibody is suitable to detect Histone H2A in samples from 人 和 小鼠. It has been validated for WB 和 IF.
产品编号 ABIN7879416
发货至: 中国
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Quick Overview for Histone H2A 抗体 (H2AS139ph) (ABIN7879416)

抗原

See all Histone H2A 抗体
Histone H2A

适用

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人, 小鼠

宿主

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小鼠

克隆类型

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单克隆

标记

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This Histone H2A antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF)
  • 抗原表位

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    H2AS139ph

    原理

    Phospho-Histone H2AX Antibody (pS139)

    纯化方法

    Antigen affinity purified

    免疫原

    The amino acid sequence surrounding phosphorylated serine 139 was used as the immunogen for the Phospho-Histone H2AX antibody.

    亚型

    IgG1, kappa
  • 应用备注

    Titration of the Phospho-Histone H2AX antibody may be required due to differences in protocols and secondary/substrate sensitivity.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    In 1X PBS, pH 7.4, with 0.09 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the Phospho-Histone H2AX antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    Histone H2A

    背景

    Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

    UniProt

    P16104
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