Recombinant Histone H2A 抗体 (H2AK118me1)
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北京 101111
Quick Overview for Recombinant Histone H2A 抗体 (H2AK118me1) (ABIN7879413)
抗原
See all Histone H2A 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- H2AK118me1
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原理
- Histone H2A (mono methyl K118) Antibody / HIST1H2AB
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纯化方法
- Affinity chromatography
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免疫原
- A synthesized peptide derived from human Histone H2A (mono methyl K118) was used as the immunogen for the Histone H2A (mono methyl K118) antibody.
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亚型
- IgG
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anti-Histone H2A (acLys9) antibody
适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Histone H2A (pSer139) antibody适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Histone H2A (H2AK95ac) antibody适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 23GB6080 unconjugated Recombinant Antibody
anti-Histone H2A (pThr120) antibody适用: 人 WB, IF, DB 宿主: 兔 Polyclonal unconjugated
anti-Histone H2A (meGln104) antibody适用: 人 WB, DB 宿主: 兔 Polyclonal unconjugated
anti-Histone H2A (ubLys119) antibody适用: 人 WB, DB 宿主: 兔 Polyclonal unconjugated
anti-Histone H2A (AA 1-15) antibody适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Histone H2A (H2AK9ac) antibody适用: 人 ELISA, IF, ICC 宿主: 兔 Monoclonal 3H5 unconjugated Recombinant Antibody
anti-Histone H2A (AA 1-128) antibody适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Histone H2A (H2AK118me1) antibody适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB6330 unconjugated Recombinant Antibody
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应用备注
- Optimal dilution of the Histone H2A (mono methyl K118) antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the Histone H2A (mono methyl K118) antibody at -20oC.
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- Histone H2A
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背景
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Histone H2A (mono methyl K118) antibody detects Histone H2A monomethylated at lysine 118, encoded by the HIST1H2AB gene. Histone H2A is a core nucleosomal protein that forms the nucleosome octamer with histones H2B, H3, and H4. Post translational modifications of histone H2A regulate chromatin structure and gene expression. Monomethylation at lysine 118 represents an important epigenetic mark associated with transcriptional regulation and genome stability. Histone H2A (mono methyl K118) antibody provides researchers with a powerful tool for epigenetic and chromatin research.
Histone modifications such as acetylation, methylation, and phosphorylation function as signals that recruit or repel regulatory proteins. Research using Histone H2A (mono methyl K118) antibody has demonstrated that lysine 118 monomethylation influences transcriptional elongation and DNA damage repair. The modification occurs in the globular domain of histone H2A, suggesting a structural impact on nucleosome stability and interactions with regulatory proteins.
In development, lysine 118 methylation has been linked to regulation of gene expression programs during differentiation. Studies with Histone H2A (mono methyl K118) antibody have shown that abnormal regulation of this mark can disrupt normal transcriptional control, leading to developmental abnormalities. The modification is also dynamically regulated in response to cellular stress, indicating its importance in adaptation and signaling.
Dysregulation of histone H2A methylation, including lysine 118, has been implicated in cancer. Research using Histone H2A (mono methyl K118) antibody has revealed that changes in this modification alter chromatin accessibility and influence oncogene or tumor suppressor gene expression. Because epigenetic states are reversible, histone modifications such as H2A K118 methylation represent potential therapeutic targets in oncology.
Histone H2A (mono methyl K118) antibody is applied in chromatin immunoprecipitation, western blotting, and immunofluorescence. Chromatin immunoprecipitation maps genome wide distribution of the modification, western blotting distinguishes specific modification states, and immunofluorescence reveals nuclear distribution patterns. These applications make Histone H2A (mono methyl K118) antibody essential for chromatin biology research.
By supplying validated Histone H2A (mono methyl K118) antibody reagents, NSJ Bioreagents supports research into epigenetic regulation, transcription, and cancer. Detection of Histone H2A monomethylated at lysine 118 provides insight into chromatin control mechanisms that underlie development and disease. -
UniProt
- P04908
抗原
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