UBE2C 抗体 (full length)
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北京 101111
Quick Overview for UBE2C 抗体 (full length) (ABIN7879293)
抗原
See all UBE2C 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- full length
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原理
- UBE2C Antibody / UBCH10 (azide and preservative free)
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纯化方法
- Protein G affinity chromatography
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免疫原
- Recombinant human full-length protein was used as the immunogen for the UBE2C antibody.
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亚型
- IgG2b, kappa
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应用备注
- Optimal dilution of the UBE2C antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the UBE2C antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- UBE2C (Ubiquitin-Conjugating Enzyme E2C (UBE2C))
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别名
- UBE2C
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背景
- The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the Ub C-terminus and the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ubconjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. UBE2C, also designated UBCH10 in human, is an E2 ubiquitin conjugating enzyme for the anaphase promoting complex (APC), which coordinates mitosis and G1 by sequentially promoting the degradation of key cell-cycle regulators. UBE2C is overexpressed in many different types of cancers and may be a potential therapeutic target.
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UniProt
- O00762
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途径
- Ubiquitin Proteasome Pathway
抗原
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