Recombinant Tumor Suppressor ARF (CDKN2A) (full length) 抗体
This 兔 单克隆 antibody specifically detects Tumor Suppressor ARF in IHC (p). It exhibits reactivity toward 人.
产品编号 ABIN7879268
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Quick Overview for Recombinant Tumor Suppressor ARF (CDKN2A) (full length) 抗体 (ABIN7879268)
抗原
Tumor Suppressor ARF (CDKN2A)
抗体类型
Recombinant Antibody
适用
人
宿主
兔
克隆类型
单克隆
标记
非结合性
应用范围
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
质量等级
Carrier-free
克隆位点
CDKN2A-8196R
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抗原表位
- full length
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原理
- P16INK4a Antibody / Cyclin-dependent kinase inhibitor 2A Antibody / CDKN2A (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- Purified recombinant prokaryotic full-length human protein was used as the immunogen for the P16INK4a antibody.
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亚型
- IgG, kappa
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anti-Tumor Suppressor ARF (CDKN2A) (AA 1-156) antibody
CDKN2A 适用: 人 FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 4A10E1 unconjugated
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应用备注
- Optimal dilution of the P16INK4a antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Aliquot the P16INK4a antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Tumor Suppressor ARF (CDKN2A)
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别名
- P16INK4a / Cyclin-dependent kinase inhibitor 2A
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背景
- P16INK4a is a tumor suppressor protein. It is a specific inhibitor of cdk4/cdk6, and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recent analyses of the p16INK4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. Although the frequency of p16INK4a abnormalities is higher in tumor derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia. Expression of p16INK4a (p16 positive) is highly correlated with human papilloma virus (HPV) infection in head and neck squamous cell carcinomas (HNSCC). p16 status is an important prognostic indicator in HNSCC and the p16 positive/HPV16 negative group is likely a distinct subgroup lacking any HPV genotype.
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UniProt
- P42771
抗原
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