Tumor Suppressor ARF (CDKN2A) (AA 72-101) 抗体
The 兔 多克隆 anti-Tumor Suppressor ARF antibody is suitable to detect Tumor Suppressor ARF in samples from 人. It has been validated for IHC (p), FACS 和 WB.
产品编号 ABIN7876617
发货至:
中国
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Quick Overview for Tumor Suppressor ARF (CDKN2A) (AA 72-101) 抗体 (ABIN7876617)
抗原
Tumor Suppressor ARF (CDKN2A)
适用
人
宿主
兔
克隆类型
多克隆
标记
非结合性
应用范围
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Western Blotting (WB)
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抗原表位
- AA 72-101
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原理
- Tumor suppressor ARF Antibody / CDKN2A / MLM
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 72-101 from the human protein was used as the immunogen for the Tumor suppressor ARF antibody.
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亚型
- Ig Fraction
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anti-Tumor Suppressor ARF (CDKN2A) (AA 1-156) antibody
CDKN2A 适用: 人 FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 4A10E1 unconjugated
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应用备注
- The stated application concentrations are suggested starting points. Titration of the Tumor suppressor ARF antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Tumor suppressor ARF antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Tumor Suppressor ARF (CDKN2A)
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别名
- Tumor suppressor ARF
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背景
- This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene, this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
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UniProt
- Q8N726
抗原
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